PURPOSE Analogues of the naturally occurring polyamines, alkylated on both terminal amines, are being developed as anticancer drugs. Because bisalkylated derivatives of putrescine (1,4-diaminobutane) are potent inhibitors of the flavin adenine dinucleotide-dependent polyamine oxidase (PAO), we asked whether PAO could detoxify synthetic bisalkylated polyamines with chain lengths longer than putr...

Abstract Background Medical treatment (MT) is key in the management of Inflammatory Bowel Disease (IBD, ulcerative colitis [UC] and Crohn’s disease [CD]) non-adherence a barrier to efficacy. Approximately 30 % patients with IBD non-adherent MT. Self-care defined as; process maintaining health through health-promoting practices managing illness. Adherence an important part self-care IBD. Illness...

We study the time of distributed deterministic broadcasting in synchronous radio networks of unknown topology and size. If a node u can be reached from two nodes which send messages in the same round, none of the messages is received by u. We assume that nodes are completely ignorant of the network: they know neither its topology, nor size, nor even their immediate neighborhood. The initial kno...

A dynamic general equilibrium model is constructed to examine the impact of mass immigration on capital accumulation in life-cycle economies. The model is calibrated to match Canadian demographic characteristics over 1861–1913. This was a period when Canada experienced a dramatic shift in migration patterns, with increasing immigration flows, and a surge in domestic savings and capital inflows....

Certain N-alkylated analogues of the natural polyamine spermine, such as N1,N11-diethylnorspermine (DENSPM), rapidly deplete intracellular polyamine pools by down-regulating the biosynthetic enzymes, ornithine decarboxylase and S-adenosylmethionine decarboxylase, and by potently up-regulating the polyamine catabolizing enzyme, spermidine/spermine N1-acetyltransferase. On the basis of previously...

This study evaluates the relevancy of economic globalization, financial development, and clean energy, in strengthening environmental sustainability next 11 economies over a time period pertaining to 1995–2018. In order achieve objective this study, advanced panel estimation techniques unit root testing, cointegration analysis have been applied due presence cross-sectional-dependence heterogene...

The Kahane–Salem–Zygmund inequality for multilinear forms in ?? spaces claims that, all positive integers m,n1,...,nm, there exists an m-linear form A:??n1×?×??nm?K (K=R or C) of the typeA(z(1),...,z(m))=?j1=1n1??jm=1nm±zj1(1)?zjm(m), satisfying?A??Cmmax?{n11/2,…,nm1/2}?j=1mnj1/2, forCm??mlog?mm! and a certain ?>0. Our main result shows that given any ?>0 integer m, N such thatCm<1+?, when we c...