Huntington’s Disease (HD) is a devastating autosomal dominanta neurodegenerative human disease for which there is currently no cure. HD is characterized by progressive motor, cognitive, and psychiatric symptoms (Huntington 1872). The gene responsible for HD (HTT) encodes the ubiquitously expressed Huntingtin protein (Htt) (MacDonald et al. 1993) (Fig. 1). Human Htt is essential for brain develo...

A sedimentological, biostratigraphic, and petrographical investigation was conducted on exposed sedimentary rocks in the Seulimeum Formation Northwest Aceh Basin, Sumatra. Sedimentary facies analysis suggests a deep-marine depositional environment consists of an inner fan, middle outer fan to basin plain deposits. New foraminiferal data designated late Miocene early Pleistocene age for studied ...

Studies of neutrophil nicotinamide adenine dinucleotide phosphate (NADPH) oxidase activation in a cell-free system showed that the low molecular-weight guanosine triphosphatase (GTPase) Rac was required, and that Rap1a may participate in activation of the catalytic complex. Full-length posttranslationally modified Rac2 was active, whereas only the 1-166 truncated form of Rap1a was functional in...

Aim: This study investigated the cultural method and 16S rRNA gene analysis to reveal composition diversity of lactic acid bacteria (LAB) from dairy origin (spontaneous fermented cow milk) in Nigeria.
 Methods: Six samples which includes two raw milk, goat milk (nono) were collected subjected standard microbiological investigation using both molecular methods. The cultured on MRS media, is...

Cyclic stretch of alveolar epithelial cells (AEC) can alter normal lung barrier function. Fibroblast growth factor-10 (FGF-10), an alveolar type II cell mitogen that is critical for lung development, may have a role in promoting AEC repair. We studied whether cyclic stretch induces AEC DNA damage and whether FGF-10 would be protective. Cyclic stretch (30 min of 30% strain amplitude and 30 cycle...

Pancreatic carcinoma cells exhibit a pronounced tendency to invade along and into intra- and extrapancreatic nerves, even at early stages of the disease. The neurotrophic factor glial cell line-derived neurotrophic factor (GDNF) has been shown to promote pancreatic cancer cell invasion. Here, we demonstrate that pancreatic carcinoma cell lines, such as PANC-1, expressed the RET and GDNF family ...

RET/papillary thyroid carcinoma (PTC) oncoproteins result from the in-frame fusion of the RET receptor tyrosine kinase with protein dimerization motifs encoded by heterologous genes. Here, we show that RET/PTC1 activates the Rap1 small GTPase. The activation of Rap1 was dependent on the phosphorylation of RET Tyr(1062). RET/PTC1 recruited a complex containing growth factor receptor binding prot...