frequent dosing of the potent anti-androgen, flutamide, is necessary to reach a therapeutic level for the treatment of prostatic carcinoma. sustained delivery of the drug could reduce the adverse effects such as gastrointestinal disorders and improve patient compliance. in the present study sustained-release matrix tablets of flutamide were prepared by direct compression method using different ...

The aim of this study was to develop an extended-release tablet formulation using a new in situ cross-linking method. The effects of polyvalent cations on theophylline release from tablets made with the polyanionic polymers sodium alginate and sodium carboxymethylcellulose, were investigated. Different miliequivalents of the di and tri-valent cation, Ca2+ and Al3+, were added to tablet form...

Introduction: Sungkai (Peronema canescens, Jack.) contains polysaccharides, terpenoids, alkaloids, and polyphenols which have pharmacological activity as immunostimulants. Objective: This study aimed to see how the effect of extract an immunostimulant agent was carried out in vitro vivo. Materials Methods: conducted using two methods, namely vivo vitro. In research method test phagocytic capaci...

Miswak.is stem of Salvadora perisca,which is particulary used by moslems for tooth brushing.cosidering the useful properties of Miswak and easy use of toothpastes.this research  is airned at toothpaste formulation from Miswak extract .toothpaste bases was formulated by use of diferrent ingrediants.some of the formulation were selected for accelerated stability test analysis.by these studies,the...

Clarithromycin (CLM) is a member of macrolide family with broad spectrum antibiotic activity. It is practically insoluble in water and its poor solubility is pH dependent. In this study, series of nanosuspensions containing CLM and stabilizer such as HPMC, NaCMC, polysorbate 80, poloxamer 188 and polyvinyl alcohol in various ratios were prepared using sonoprecipitation method. Briefly, CLM was ...

Polymeric nanostructures for drug delivery applications including smart hydrogels and stealth micelles have been developed to overcome many obstacles in the way of timing and targeting the delivery to fulfill therapeutic potentiality of chemicals. The purpose of this investigation is to prepare and characterize novel nanoparticle-based colloidal products composed of biocompatible polymers to us...

Abstrak
 Kerusakan hati menjadi salah satu penyakit dengan prevalensi yang tinggi khususnya di negara berkembang. Penelitian ini bertujuan untuk melihat adanya efek ekstrak ethanol daun kelor (Moringa oleifera) terhadap proteksi fungsi dan histopatologi tikus putih (Rattus norvegicus) diinduksi karbontetraklorida (ccl4). serta menentukan dosis efektif dari kombinasi tersebut. dilakukan sec...