Salmonella enterica serovar Virchow is highly prevalent in humans and farm animals in Israel. In addition to high rates of resistance to multiple antibiotics, this serovar exhibits a high incidence of resistance to nalidixic acid. More than 90% of Salmonella serovar Virchow isolates of human and poultry origin obtained from 1997 to 2004 were resistant to nalidixic acid (MIC > or = 128 microg/ml...

Background and Objectives: Urinary tract infections (UTI) are one of the most common infectious diseases with different microbial agent and antimicrobial resistant pattern in hospitalized patients and outpatients. In order to assess the adequacy of therapy, knowledge of prevalence and resistance pattern of the bacteria is necessary. The main aim of this study was to evaluate the prevalence and ...

The phenotypic characterization and antibiotic susceptibility patterns of 72 environmental isolates of Vibrio spp. collected from six aquaculture sites along the west coast of Sabah, Borneo, Malaysia was investigated. Up to 21 conventional biochemical tests were carried out and the sensitivity of the isolates against 16 antibiotics were tested using the disk diffusion method. In the present stu...

cholestatic hepatitis induced by prolonged administration of nalidixic acid: anti biotics like other drugs may generally produce hepatic benign lesions. we have recently observed a case of cholestatic hepatitis by prolonged administration of nalidixic acid. this hepatitis have regressed rapidly after discont inuin-c the dru g. this case dose not excluded the value of nalidixic acid asa strong a...

Campylobacter is one of the most common bacterial enteropathogens of food borne origin in industrialized countries with C. jejuni being the most common species followed by C. coli. The prevalence of Campylobacters in and around Chandigarh, India was studied by phenotypic and genotypic methods. Fecal samples from 1145 diarrheal patients and 102 healthy subjects from hospital and community were c...

We studied 100 well-characterized E. coli blood isolates from patients with urosepsis for their susceptibility to nalidixic acid, ampicillin and trimethoprim-sulfamethoxazole, according to prevalence of virulence factors, phylogenetic groups and subgroups, PAI II(J96)-like domains (determined by physical linkage of cnf1, hly and hra) and PAI I(CFT073)-like domains (determined by physical linkag...

Inhibitors of DNA gyrase in Escherichia coli exerted differential effects on the genetic transformation of Neisseria gonorrhoeae. When competent cells of the gonococcus were exposed to novobiocin before the uptake of transforming antibiotic resistance DNA, there was a 50 to 60% reduction in the number of transformants compared with the number of control untreated cells. Norfloxacin, a more pote...

ParC proteins. The results show that the use of 20 mg/L of Phe-Arg-β-naphthylamide decreased the MIC of nalidixic acid (from two to five serial twofold dilution steps) in all isolates tested, even in those with the nalidixic acid-susceptible phenotype. This high reduction in the MIC values was observed independent of the number of amino acid changes in GyrA and ParC. This effect was especially ...

UNLABELLED Urinary tract infections (UTI) are one of the most common infections with an increasing resistance to antimicrobial agents. PURPOSE Empirical initial antibiotic treatment of UTI must rely on susceptible data from local studies. MATERIALS AND METHODS Retrospective analysis of isolated bacteria from children with UTIs was performed at the university hospital during years 2006-2009....

Pipemidic acid, 8-ethyl-5,8-dihydro-5-oxo-2-(1-piperazinyl)-pyrido [2,3-d]pyrimidine-6-carboxylic acid, is a new derivative of piromidic acid. It is active against gram-negative bacteria including Pseudomonas aeruginosa as well as some gram-positive bacteria. Its potency is generally greater than that of piromidic acid and nalidixic acid. Cross-resistance is not observed between pipemidic acid ...