The 21st century has seen a paradigm shift to inhaled therapy, for both systemic and local drug delivery, due to the lung's favourable properties of a large surface area and high permeability. Pulmonary drug delivery possesses many advantages, including non-invasive route of administration, low metabolic activity, control environment for systemic absorption and avoids first bypass metabolism. H...

Nano Enabled Drug Delivery (NEDD) systems are rapidly emerging as a key sub-area of nanotechnology’s application. Drug Delivery Systems (DDS) can improve the administration and efficacy of pharmaceutical compounds including antibodies, peptides, vaccines, drugs and enzymes [1]. As one subset of drug delivery innovation, NEDD, in which the small molecule delivery systems are at the submicron sca...

ABBREVIATIONS: μmMicrometer, nmNanometer, PMMA Poly (methylmethacrylate), PACA Poly (alkylcyanoacrylate), PMM Poly (methylidenemalonate), SME Sub-micron emulsion, PAMAM Polyamido amines, 5-ASA 5-Aminosalicylic acid, McMolar mass of the core, MmMolar mass of the branched monomer, MtMolar mass of the terminal groups, ncCore multiplicity, nmBranch-juncture multiplicity, GGeneration number, CMCCrit...

Coronary artery disease, in the development of which inflammation mediated by innate immune cells plays a critical role, is one of the leading causes of death worldwide. The 3-hydroxy-3-methylglutaryl coenzyme A reductase inhibitors (statins) are a widely used lipid-lowering drug that has lipid-independent vasculoprotective effects, such as improvement of endothelial dysfunction, antioxidant pr...

The objective of present work was development of felodipine nano emulsion formulations using sesame oil as sole lipid phase by high pressure homogenization technique. A combination of non-ionic surfactants was used based on HLB (Hydrophilic lipophilic balance) values. The resultant nano emulsions were characterized for particle size, zeta potential. The particle size for the optimized nano emul...

In this work, the electronic properties of BP and CSi Nano cones have been investigated by self-consistent reaction field (SCRF) method in water solvent at B3PW91/6-31G (d,p) level of DFT theory for study of  for interactions of 5-Fluorouracil Anticancer Drug with theses Nano cones. The percent of change of energy gap (%ΔEg) shows that the complex formation of 5-Fluorouracil with BP ...