The Nucleus of the Solitary Tract (NTS) receives gustatory and visceral information from afferent fibers in the vagus and projects to the Nucleus Paragigantocellularis (PGi), among several other brain region. PGi sends excitatory fibers, mostly glutamatergic, to the Locus Coeruleus (LC). In turn, LC sends noradrenergic projections to many areas of the brain, including hippocampus (HIPP) and amy...

In order to investigate the gas separation ability of a column packed with nanozeolitic material, nano NaY zeolite was synthesized and granulated. These uniform granules packed in a chromatographic column were utilized for separation of Xe and Kr under various operating conditions. With regards to the response peaks obtained from trace injections of Xe and Kr into the column, the first and seco...

IN T RO DU C T IO N Insulin is perhaps one of the best known and earliest peptide therapeutics. Multiple long and fast-acting analogs have also been developed, and a patient may often be prescribed one of each for diabetes control. Quantification of biologics, such as insulins, has historically been performed using ligand binding assays (LBAs) such as ELISAS. LC/MS/MS, however, has certain adva...

The development of a multidimensional approach involving high-performance liquid chromatography (LC), ion mobility spectrometry (IMS) and tandem mass spectrometry is described for the analysis of complex peptide mixtures. In this approach, peptides are separated based on differences in their LC retention times and mobilities (as ions drift through He) prior to being introduced into a quadrupole...

Modern determination techniques for pesticides must yield identification quickly with high confidence for timely enforcement of tolerances. A protocol for the collection of liquid chromatography (LC) electrospray ionization (ESI)-quadruple linear ion trap (Q-LIT) mass spectrometry (MS) library spectra was developed. Following the protocol, an enhanced product ion (EPI) library of 240 pesticides...

A rapid method for the quantification of five ribonucleotides 5'- monophophates (adenosine, cytidine, guanosine, inosine, uridine, 5'-monophosphate), in infant formula, has been proposed using nano-LC. To separate the studied compounds, capillary columns packed with different C18-based stationary phases were investigated. All the columns tested were laboratory prepared. The experiments were per...

After joining the faculty at Toyohashi University of Technology (TUT) in 1978, the author has found two areas in separation sciences where microcolumn liquid chromatography (micro-LC) can be beneficial. One is the hyphenated techniques between many spectroscopic methods such as mass (MS), infrared (FT-IR) and atomic emission (ICP), and micro-LC. The other one is rather difficult, but basic and ...

Statement of Purpose: Various nanoparticle systems with a long blood circulation time and a high tumor accumulation have been reported for cancer diagnosis and treatment based on their EPR (enhanced permeability and retention) effect [1,2]. Here, we prepared several Pluronic-based nano-carriers attached with an NIR dye, and characterized their cellular uptake and in-vivo tumor targeting efficie...

We present a new fully self-aligned single-electron memory with a single pair of nano floating gates, made of different materials (Si and Ge). The energy barrier that prevents stored charge leakage is induced not only by quantum effects but also by the conduction-band offset that arises between Ge and Si. The dimensions and position of each floating gate are well-defined and controlled. The dev...