نتایج جستجو برای: nanobodies
تعداد نتایج: 541 فیلتر نتایج به سال:
Post-translational modifications are difficult to visualize in living cells and are conveniently analyzed using antibodies. Single-chain antibody fragments derived from alpacas and called nanobodies can be expressed and bind to the target antigenic sites in living cells. As a proof of concept, we generated and characterized nanobodies against the commonly used biomarker for DNA double strand br...
Astrocytes, the main Central Nervous System (CNS) glial cell type, actively release transmitters, including glutamate, and thereby participate in physiological brain information processing. However, dysregulated transmitter from astrocytes can contribute to CNS disease pathogenesis progression. Therefore, targeting astrocyte glutamate is a promising new therapeutic strategy hyper-glutamatergic ...
Background Binding proteins such as antibodies are useful for basic science, diagnosis, and therapy. Nanobodies also promising binding that achieve comparable affinities specificities to conventional antibodies, despite comprising only a single 15 kDa variable domain. The generation of functional nanobodies typically involves phage, yeast, or ribosome display, which allows screening billions si...
Sera of camelids contain both conventional heterotetrameric antibodies and unique functional heavy (H)-chain antibodies (HCAbs). The H chain of these homodimeric antibodies consists of one antigen-binding domain, the VHH, and two constant domains. HCAbs fail to incorporate light (L) chains owing to the deletion of the first constant domain and a reshaped surface at the VHH side, which normally ...
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