Mild non-ionic sucrose ester surfactants can be employed to produce lipid-based drug delivery systems for dermal application. Moreover, sucrose esters of intermediate lipophilicity such as sucrose stearate S-970 possess a peculiar rheological behavior which can be employed to create highly viscous semi-solid formulations without any further additives. Interestingly, it was possible to develop b...

Over the last decade, nanoemulsion-based delivery systems have been gained interest in the pharmaceuticals1-4, food and beverage5-8, cosmetics9-11, agrochemicals12-14 and other15 industries. The main purposes are to encapsulate, protect, and deliver lipophilic components such as drugs, vitamins, food supplements, antioxidants, antimicrobials, pesticides. In general, it is desirable to utilize n...

The paper reports the results of nanotherapy of ovarian, breast, and pancreatic cancerous tumors by paclitaxel-loaded nanoemulsions that convert into microbubbles locally in tumor tissue under the action of tumor-directed therapeutic ultrasound. Tumor accumulation of nanoemulsions was confirmed by ultrasound imaging. Dramatic regression of ovarian, breast, and orthotopic pancreatic tumors was o...

−Stable hydrocarbon oil (hexadecane, C16)/nonionic surfactant (HCO-60, Span 80)/water system oil-inwater nanoemulsions were prepared by the phase inversion composition method at elevated temperature. To minimize droplet size, the composition ratio for stable nanoemulsions, we experimented by changing the HLB value, oil/surfactant ratio, and droplet volume fraction. When the HLBmix value 11, the...

Fluorine-19 magnetic resonance imaging ((19)F MRI) probes enable quantitative in vivo detection of cell therapies and inflammatory cells. Here, we describe the formulation of perfluorocarbon-based nanoemulsions with improved sensitivity for cellular MRI. Reduction of the (19)F spin-lattice relaxation time (T1) enables rapid imaging and an improved signal-to-noise ratio, thereby improving cell d...

Sterically stabilized diblock copolymer nanoparticles with an intensity-average diameter of 25 nm are prepared in the form of a concentrated aqueous dispersion using polymerization-induced self-assembly (PISA). The addition of n-dodecane followed by high-shear homogenization produces n-dodecane-in-water Pickering macroemulsions of 22-46 μm diameter. If the nanoparticles are present in sufficien...

In the present study, tocotrienol rich fraction (TRF) nanoemulsions were produced as an alternative approach to improve solubility and absorption of tocotrienols. In the present study, droplet size obtained after 10 cycles of homogenization with increasing pressure was found to decrease from 120 to 65.1 nm. Nanoemulsions stabilized with Tween series alone or emulsifier blend Brij 35:Span 80 (0....

The topical delivery of non-steroidal anti-inflammatory drugs (NSAIDS) such as Ibuprofen has been explored as a potential method of avoiding the first pass effects and the gastric irritation, which may occur when used orally. Ibuprofen is formulated into many topical preparations to reduce the adverse effects and simultaneously avoid the hepatic first-pass metabolism as well. However, it is dif...

According to the loss of food due expired shelf life, there is a global concern on safety among science researchers, and microbiologists. So, any approaches contributing improved packaging most welcome. It has been demonstrated that administration essential oils, fades away unsolved obstacles conventional packaging, reducing environmental concerns compared with packaging. Along substantial prog...