Electrospun nanofibrous scaffolds have become widely investigated for tissue engineering applications, owing to their ability to replicate the scale and organization of many fiber-reinforced soft tissues such as the knee meniscus, the annulus fibrosus of the intervertebral disc, tendon, and cartilage. However, due to their small pore size and dense packing of fibers, cellular ingress into elect...

Nanofibrous scaffolds with specific modifications have shown promising potential for bone tissue engineering applications. In the present study, poly(ether sulfone) (PES) and sulfonated PES (SPES) nanofibers were fabricated via electrospinning. Calcium ions were then incorporated in SPES by immersion in a Ca(OH)2 solution. The calcium-ion-exchanged SPES (Ca-SPES), PES, and SPES nanofibers were ...

stem cell research has obtained much prominence in recent years for its therapeutic potential in dealing with serious diseases, many of which are essentially incurable by routine therapies. mesenchymal stem cells with pluripotency and immunomodulatory properties are suitable candidates for tissue engineering and regenerative medicine. today, nanofibrous scaffolds are widely used in tissue engin...

Self-assembled synthetic materials are typically disordered, and controlling the alignment of such materials at the nanometer scale may be important for a variety of biological applications. In this study, we have applied directional freeze-drying, for the first time, to develop well aligned three dimensional (3D) nanofibrous materials using amino acid like L-phenylalanine (Phe). 3D free-standi...

cartilage is an avascular, aneural, and alymphatic connective tissue with a limited capacity caused by low mitotic activity of its resident cells, chondrocytes. natural repair of full thickness cartilage defects usually leads to the formation of fibrocartilage with lower function and mechanical force compared with the original hyaline cartilage and further deterioration can occur. tissue engine...

A novel nanofibrous composite scaffold composed of super-paramagnetic γ-Fe2O3 nanoparticles (MNP), hydroxyapatite nanoparticles (nHA) and poly lactide acid (PLA) was prepared using electrospinning technique. The scaffold well responds extern static magnetic field with typical saturation magnetization value of 0.049 emu/g as well as possesses nanofibrous architecture. The scaffolds were implante...

Many studies have demonstrated that in vitro shear stress conditioning of endothelial cell-seeded small-diameter vascular grafts can improve cell retention and function. However, the laminar flow and pulsatile flow conditions which are commonly used in vascular tissue engineering and hemodynamic studies are quite different from the actual physiological pulsatile flow which is pulsatile in natur...

To better engineer small-diameter blood vessels, a few types of novel scaffolds were fabricated from biodegradable poly(L-lactic acid) (PLLA) by means of thermally induced phase separation (TIPS) techniques. By utilizing the differences in thermal conductivities of the mold materials, the scaffolds with oriented gradient microtubular structures in axial or radial direction were created using be...