Background: Psoriasis is a widespread chronic disease affecting 1-3% of total population and in most cases, treated by topical application corticosteroids. Though, the route very demanding because physicochemical nature diseased stratum corneum so no, single treatment works for every patient. The oral evidence harsh side effects systemic immunosuppression which can be avoided route. Objectives:...

BACKGROUND Berberine hydrochloride is a conventional component in Chinese medicine, and is characterized by a diversity of pharmacological effects. However, due to its hydrophobic properties, along with poor stability and bioavailability, the application of berberine hydrochloride was hampered for a long time. In recent years, the pharmaceutical preparation of berberine hydrochloride has improv...

The present study was aimed at formulating thermoreversible in situ gel of local anesthetic by using xyloglucan based mucoadhesive tamarind seed polysaccharide (TSP) into periodontal pocket. Temperature-sensitive in situ gel of lidocaine hydrochloride (LH) (2% w/v) was formulated by cold method. A full 3(2) factorial design was employed to study the effect of independent variables concentration...

Core-shell 12-tungstophosphoric acid/TiO2 (HPW/TiO2) nanoparticles at 10 and 20% of HPW have been synthesized by simple in-situ sol- gel method. Characterization of the samples was carried out by X-ray diffraction (XRD), Scanning electron microscopy (SEM), Fourier transform infrared (FTIR). The X-ray diffraction patterns of as prepared solid samples, indicated characterist...

Nanoparticulate imaging agents and therapeutics have proven to be valuable tools in preclinical cardiovascular disease research. Because of their distinct properties and significant functional versatility, nanoparticulate imaging agents afford certain capabilities that are typically not provided by traditional small molecule agents. This review is the second in a two-part series covering nanopa...

The targeted delivery of therapeutics to tumors remains an important challenge in cancer nanomedicine. Attaching nanoparticles to cells that have tumoritropic migratory properties is a promising modality to address this challenge. Here we describe a technique to create nanoparticulate cellular patches that remain attached to the membrane of cells for up to 2 days. NeutrAvidin-coated nanoparticl...

Delivery of tissue glues through small-bore needles or trocars is critical for sealing holes, affixing medical devices, or attaching tissues together during minimally invasive surgeries. Inspired by the granule-packaged glue delivery system of sandcastle worms, a nanoparticulate formulation of a viscous hydrophobic light-activated adhesive based on poly(glycerol sebacate)-acrylate is developed....

Core-shell 12-tungstophosphoric acid/TiO2 (HPW/TiO2) nanoparticles at 10 and 20% of HPW have been synthesized by simple in-situ sol- gel method. Characterization of the samples was carried out by X-ray diffraction (XRD), Scanning electron microscopy (SEM), Fourier transform infrared (FTIR). The X-ray diffraction patterns of as prepared solid samples, indicated characterist...

sound power is considered as an excellent measure for evaluating the efficiency of noise controls as well as for comparing noise sources in workrooms. this parameter can be determined by sound pressure or intensity based methods in real conditions of workrooms. this paper aims empirically to compare these in situ methods in relation to a typical industrial machine located in workroom in terms o...