Type B gelatin-based engineered nanovectors system (GENS) was developed for systemic gene delivery in the treatment of pancreatic cancer. The surface of thiolated gelatin nanoparticles was modified with epidermal growth factor receptor (EGFR) specific peptide that targets on the EGFR receptor of Panc-1 cells and this system could release the payload under reducing environment, such as high intr...

The field of specific drug delivery is an expanding research domain. Besides the use of liposomes formed from various lipids, natural and synthetic polymers have been developed to prepare more efficient drug delivery systems either under macromolecular prodrugs or under particulate nanovectors. To ameliorate the biocompatibility of such nanocarriers, degradable natural or synthetic polymers hav...

Today, neurodegenerative diseases are affecting more and individuals. A typical therapeutic target to treat the progression of symptoms related these is proinflammatory microglia. Diapocynin, dimeric version apocynin, often drug choice. However, suitable carriers for its controlled delivery currently lacking in clinics. In fact, high hydrophilicity hampers development a formulation enabling sus...

Drug delivery by nanomaterials is an active emergent research area and CNTs draws considerable potential application owing to its unique quasi one-dimensional structure and electronic properties. Single walled carbon nanotubes and carbon fullerenes can be used in drug delivery due to their mechanical and chemical stability. The past few years, increasing attention by several reputed groups has ...

Therapies targeted to the immune system, such as immunotherapy, are currently shaping a new, rapidly developing branch of promising cancer treatments, offering the potential to change the prognosis of previously non-responding patients. Macrophages comprise the most abundant population of immune cells in the tumor microenvironment (TME) and can undergo differentiation into functional phenotypes...