A polyp is an oedematous mucous membrane which forms a pedunculating process with a slim or broad stalk or base. Nasal polyps originate in the upper part of the nose around the openings to the ethmoidal sinuses. The polyps extend into the nasal cavity from the middle meatus, resulting in nasal blockage and restricted airflow to the olfactory region. The polyp stroma is highly oedematous with a ...

Nasal polyps are common, affecting up to four percent of the population. Their etiology remains unclear, but they are known to have associations with allergy, asthma, infection, cystic fibrosis, and aspirin sensitivity. They present with nasal obstruction, anosmia, rhinorrhoea, post nasal drip, and less commonly facial pain. Clinical examination reveals single or multiple grey polypoid masses i...

OBJECTIVE To assess the efficacy and safety of fluticasone propionate administered using OptiNose's novel delivery device (Opt-FP) in subjects with bilateral mild-to-moderate nasal polyposis. METHODS A prospective, multicentre, randomized, double-blind, placebo-controlled, parallel group study was conducted in adult subjects (n = 109) with mild-to-moderate bilateral nasal polyposis. Subjects ...

BACKGROUND To determine the effect of intranasal sodium hyaluronate on mucociliary clearance time following functional endoscopic sinus surgery in patients with nasal polyposis. STUDY DESIGN Randomized, controlled, blinded study. METHODS Thirty-six patients with grade II nasal polyposis undergoing functional endoscopic sinus surgery received intranasal sodium hyaluronate 9 mg twice daily or...

Seasonal and perennial allergic rhinitis, acute rhinosinusitis and nasal polyposis are inflammatory conditions of the nose and/or sinuses that produce bothersome symptoms and markedly affect patients’ quality of life [1–3]. These diseases frequently coexist, suggesting that each may be a manifestation of an inflammatory process within the continuous airway [3–5]. Clinical treatment guidelines f...

OBJECTIVES The pathogenesis of sinonasal polyposis remains unclear, in spite of several investigative approaches. Antrochoanal polyps, a subgroup of sinonasal polyposis along with allergic- and chronic-inflammatory nasal polyps, mostly originate from the maxillary sinus and develop as a unilateral, pedunculated mass towards the nasopharynx. The human papillomavirus (HPV) is discussed as a possi...

OBJECTIVE To evaluate TGF-β1 expression in polypoid mucosa (epithelium and stroma) of patients with chronic rhinosinusitis with nasal polyposis (CRSwNP). METHODS Cross-sectional study with two groups: 17 patients with nasal polyposis and 11 controls. Polyps and normal nasal mucosa were processed by immunohistochemical methods for TGF-β1 visualization. Then, the percentage of TGF-β1 expression...

Nonallergic rhinitis with eosinophilia syndrome (NARES) is a clinical syndrome comprising symptoms consistent with allergic rhinitis in which an absence of atopy has been demonstrated by allergen skin testing, and nasal cytology analysis demonstrates more than 20% eosinophils. Anosmia is a prominent feature not shared with allergic rhinitis. The pathophysiology of NARES is poorly understood, bu...

Dear Editor, Nasal polyp is a common chronic inflammatory disease of the sinonasal mucosa that is histologically characterized by infiltration of eosinophils and large quantities of extracellular edema. It causes considerable morbidity such as nasal obstruction, rhinorrhea and sleep disorders. Pathogenesis of nasal polyps is still debatable. Helicobacter pylori may play a role in the pathogenes...