We study the complexity of computing Nash equilibria in games where players arranged as the vertices of a graph play a symmetric 2-player game against their neighbours. We call this a pairwise interaction game. We analyse this game for n players with a fixed number of actions and show that (1) a mixed Nash equilibrium can be computed in constant time for any game, (2) a pure Nash equilibrium ca...

Using the method of generic continuity of set-valued mappings, this paper studies the stability of weakly Pareto-Nash and Pareto-Nash equilibria for multiobjective population games, when payoff functions are perturbed. More precisely, the paper investigates the continuity properties of the set of weakly Pareto-Nash equilibria and that of the set of Pareto-Nash equilibria under sufficiently smal...

Non-alcoholic steatohepatitis (NASH) can lead to advanced fibrosis, hepatocellular carcinoma, and end-stage liver disease requiring liver transplantation. A myriad of pathways and genetic influence contribute to NASH pathogenesis and liver disease progression. Diagnosing patients with NASH and advanced fibrosis is critical prior to treatment and prognostication. There has been ongoing interest ...

The equilibrium problem with equilibrium constraints (EPEC) can be looked on as a generalization of Nash equilibrium problem (NEP) and the mathematical program with equilibrium constraints (MPEC) whose constraints contain a parametric variational inequality or complementarity system. In this paper, we particularly consider a special class of EPECs where a common parametric P-matrix linear compl...

AIM To evaluate the pharmacodynamics of compounds in clinical development for nonalcoholic steatohepatitis (NASH) in obese mouse models of biopsy-confirmed NASH. METHODS Male wild-type C57BL/6J mice (DIO-NASH) and Lep ob/ob (ob/ob-NASH) mice were fed a diet high in trans-fat (40%), fructose (20%) and cholesterol (2%) for 30 and 21 wk, respectively. Prior to treatment, all mice underwent liver...

BACKGROUND Non-alcoholic steatohepatitis (NASH) is often seen together with components of metabolic syndrome. The aim of this study was to assess the risk of de novo post-transplant type 2 diabetes (DM) in liver transplant recipients with NASH. METHODS All adult patients from the Scientific Registry of Transplant Recipients (2003-2012) transplanted for NASH or cryptogenic cirrhosis (the NASH ...

BACKGROUND/AIMS Adipose tissue is an active endocrine organ that secretes various metabolically important substances including adipokines, which represent a link between insulin resistance and nonalcoholic steatohepatitis (NASH). The factors responsible for the progression from simple steatosis to steatohepatitis remain elusive, but adipokine imbalance may play a pivotal role. We evaluated the ...

BACKGROUND & AIMS In recent years, nonalcoholic steatohepatitis (NASH) has become a considerable healthcare burden worldwide. Pathogenesis of NASH is associated with type 2 diabetes mellitus (T2DM) and insulin resistance. However, a specific drug to treat NASH is lacking. We investigated the effect of the selective sodium glucose cotransporter 2 inhibitor (SGLT2I) ipragliflozin on NASH in mice....

BACKGROUND AND AIM It is recognized that nonalcoholic fatty liver disease (NAFLD), including nonalcoholic steatohepatitis (NASH), may develop after pancreaticoduodenectomy (PD). However, the mechanism of NASH development remains unclear. This study aimed to examine the changes in gene expression associated with NASH occurrence following PD. METHODS The expression of genes related to fatty aci...