The activation of human plasminogen by streptokinase has been the subject of extensive investigation (4-8). There appears to be general agreement that at least two enzymatic activities are demonstrable in streptokinase-plasminogen reaction mixtures. One is the proteolytic enzyme human plasmin, characterized in part by its ability to hydrolyze lysine and arginine esters and protein substrates su...

Streptokinase (SK) is being increasingly used in the treatment of acute myocardial infarction and ischemic stroke. The feeding control method using substrate balance equations is vital to maintain the preferred specific growth rate for the high-level expression of recombinant proteins. In this study, initial experiments on chemical and temperature inducible expression systems were carried out t...

Peak serum C-reactive protein concentrations were measured in 146 patients randomized to receive streptokinase, alteplase, or a combination of streptokinase and alteplase in the GUSTO-I trial. Those receiving alteplase treatment had lower values than those receiving streptokinase or the combination treatment. Irrespective of treatment, complete reperfusion of the infarct-related artery (TIMI gr...

Failure of hemostasis and the formation blood clots in arteries are main reasons that provoke onset cardiovascular diseases (CVDs) such as myocardial infarction ischemic stroke. Cardiovascular have become primary cause deaths disabilities across globe. Therefore, this problem needs to be addressed with urgency. The disintegration requires fibrinolytic agents, which involved thrombolysis. Strept...

BACKGROUND Streptokinase is a routinely used thrombolytic agent that is immunogenic and relatively inefficient toward platelet-rich thrombus, whereas staphylokinase is a poorly studied fibrinolytic agent. Here, the comparative immunogenicity and thrombolytic properties toward arterial platelet-rich thrombus and venous whole blood clots of streptokinase and recombinant staphylokinase were studie...

Rationale: The term “fragmentation of the QRS complex” denotes existence high-frequency potentials (spikes) in QRS-complex. It is either a marker for cardiac structural diseases inducing biventricular hypertrophy or any condition interfering with normally homogeneous depolarization status inside myocardium. An associated right ventricular infarction inferior maybe carry risk impact and serious ...

BACKGROUND The value of routine administration of intravenous thrombolytic agents during percutaneous transluminal coronary angioplasty (PTCA) therapy of acute myocardial infarction (MI) has not been determined. Therefore, we prospectively randomized 122 patients with evolving MI to PTCA therapy with or without adjunctive intravenous streptokinase therapy. METHODS AND RESULTS Patients with EC...

BACKGROUND Intrapleural fibrinolytic agents are used in the drainage of infected pleural-fluid collections. This use is based on small trials that did not have the statistical power to evaluate accurately important clinical outcomes, including safety. We conducted a trial to clarify the therapeutic role of intrapleural streptokinase. METHODS In this double-blind trial, 454 patients with pleur...

adverse reactions of streptokinase in patients with or without hydrocortisone injection nasiri m*1 , rahimian b2, bashiri t 3, salmalian f4 received: 25 april, 2010 accepted: 27 july, 2010 abstract background & aims: streptokinase is one of the most useful drugs in acute myocardial infarction. researches show that timely given injection of streptokinase decreases total mortality. allergic react...

OBJECTIVE To devise assays to assess and follow the specific antibody response in patients treated with streptokinase for acute myocardial infarction. DESIGN Venous blood samples were collected before treatment with streptokinase started and subsequently at regular intervals over one year. Specific IgG and subclass IgG1 were assessed by an enzyme linked immunosorbent assay. SETTING Coronary...