Background/Aim: A number of biologically active substances were proved as an alternative to conventional anticancer medicines. The aim the study is in vitro investigation activity mono- and di-Rhamnolipids (RL-1 RL-2) against human breast cancer. Additionally, combination with Cisplatin was analyzed. Materials Methods: Breast cell lines (MCF-10A, MCF-7 MDA-MB-231) treated RLs Cisplatin. viabili...

We have developed "protein- and cell-based screen methods" for the isolation of new natural products. By using VDR (vitamin D receptor) immobilized magnetic beads, two new natural products were isolated rapidly. To find inhibitors of Hes1 protein, which is one of the important transcriptional factors in neural stem cells, a Hes1 dimer plate assay was developed, and then first Hes1 dimer inhibit...