نتایج جستجو برای: nefopam

تعداد نتایج: 178  

Journal: :Proceedings of the National Academy of Sciences of the United States of America 2012
Elisabet Gregori-Puigjané Vincent Setola Jérôme Hert Brenda A Crews John J Irwin Eugen Lounkine Lawrence Marnett Bryan L Roth Brian K Shoichet

Notwithstanding their key roles in therapy and as biological probes, 7% of approved drugs are purported to have no known primary target, and up to 18% lack a well-defined mechanism of action. Using a chemoinformatics approach, we sought to "de-orphanize" drugs that lack primary targets. Surprisingly, targets could be easily predicted for many: Whereas these targets were not known to us nor to t...

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