OBJECT A Bayesian network meta-analysis (NMA) was conducted to estimate the overall survival (OS) and complete response (CR) performance in nasopharyngeal carcinoma (NPC) patients who have been given the treatment of radiotherapy, concurrent chemoradiotherapy (C), adjuvant chemotherapy (A), neoadjuvant chemotherapy (N), concurrent chemoradiotherapy with adjuvant chemotherapy (C+A), concurrent c...

Targeted therapies have markedly improved the management of patients with advanced non-small-cell lung cancer (NSCLC), but their efficacy in localized NSCLC is less well established. The aim of this review is to analyze trials of targeted therapies in localized NSCLC. In patients with wild-type EGFR, tyrosine kinase inhibitors have shown no efficacy in Phase III trials. Few data are available f...

In 2009, an estimated 40,870 new cases of rectal cancer will be diagnosed in the USA. After decades of treating metastatic colorectal cancer (CRC) with 5-fluorouracil alone, newer agents have resulted in significant improvements in disease-free and overall survival rates. These improvements stem from combinations of newer cytotoxic agents and targeted therapies. Based on performance status and ...

introduction: osteosarcoma is the most common primary bone tumor in children and young adults and appropriate chemotherapy can increase limb sparing and overall survival. yet, the toxicity of chemotherapy regimens including mtx can be life threatening. therefore; we tried another chemotherapy regimen for these patients. method and materials: we investigated 15 patients aged 15 to 40 years old a...

background: osteosarcoma is the most common bone sarcoma, and the third most common malignancy in children and adolescents. before 1970, amputation was the sole treatment. eighty percent of patients died from metastatic diseases, most commonly in the lungs. over the past three decades, effective neoadjuvant (preoperative) and adjuvant (postoperative) chemotherapy protocols have improved the abi...

tumor size seems to be a determinant in the prognosis of early cervical cancer. patients with tumor size greater than 4 cm (bulky) in diameter have worse outcome.' the purpose of this study was to compare the efficacy of preoperative combined chemoradiation and neoadjuvant chemotherapy (narc) programs followed by radical hysterectomy in stage ib - lib bulky cervical cancer. from september ...

Abstract Aims Perioperative oncological therapies resulting in complete pathological response diffuse type distal gastric adenocarcinoma are extremely rare. We report the first case of regression a patient with locally advanced (CT3N2M0) who received “total neoadjuvant” chemotherapy FLOT due to COVID pandemic. Methods & Results A 73-year-old male was diagnosed cT3N2M0 adenocarcinoma. He 4 c...