Nephrotic syndrome is an uncommon complication of tetralogy of Fallot and has been rarely reported in pediatric population. We describe a 4-year-old female Congolese child who was referred for investigation for persistent dyspnea, edema, and cyanosis and nephrotic range proteinuria. Our patient presented with a tetralogy of Fallot and nephrotic syndrome. Conclusion. This case reminds us that ch...

Abnormal folding of -synuclein ( -syn) is thought to lead to neurodegeneration and the characteristic symptoms of Lewy body disease (LBD). Since previous studies suggest that immunization might be a potential therapy for Alzheimer’s disease, we hypothesized that immunization with human (h) -syn might have therapeutic effects in LBD. For this purpose, h syn transgenic (tg) mice were vaccinated w...

We examined the changes in serum, liver, kidney, brain, and muscle L-tryptophan (Trp) levels in rats with puromycin aminonucleoside (PAN) nephrosis following oral Trp administration in order to elucidate the fate of elevated Trp in the blood of PAN nephrotic rats with oral Trp administration in their body. Before administration, nephrotic rats had higher liver and kidney Trp contents and lower ...

The proposal in this document is Experimental. While it may be deployed in the current Internet, it does not represent a consensus that this is the best possible mechanism for the use of Explicit Congestion Notification (ECN) in TCP SYN/ACK packets. This document describes an optional, experimental modification to RFC 3168 to allow TCP SYN/ACK packets to be ECN-Capable. For TCP, RFC 3168 specif...

Cytoplasmic inclusions containing alpha-synuclein (alpha-Syn) fibrils, referred to as Lewy bodies (LBs), are the signature neuropathological hallmarks of Parkinson's disease (PD). Although alpha-Syn fibrils can be generated from recombinant alpha-Syn protein in vitro, the production of fibrillar alpha-Syn inclusions similar to authentic LBs in cultured cells has not been achieved. We show here ...

Mutations in -synuclein ( -Syn) cause Parkinson’s disease (PD) in a small number of pedigrees with familial PD. Moreover, -Syn accumulates as a major component of Lewy bodies and Lewy neurites, intraneuronal inclusions that are neuropathological hallmarks of PD. To better understand the pathogenic relationship between alterations in the biology of -Syn and PD-associated neurodegeneration, we ge...

Abnormal α-synuclein (α-syn) accumulation in the CNS may underlie neuronal cell and synaptic dysfunction leading to motor and cognitive deficits in synucleinopathies including Parkinson's disease (PD) and Dementia with Lewy Bodies (DLB). Multiple groups demonstrated α-syn accumulation in CNS accessory structures, including the eyes and olfactory terminals, as well as in peripheral organs of Par...

Patients with primary membranous nephropathy (MN) who experience spontaneous remission of proteinuria generally have an excellent outcome without need of immunosuppressive therapy. It is, however, unclear whether non-nephrotic proteinuria at the time of diagnosis is also associated with good prognosis since a reasonable number of these patients develop nephrotic syndrome despite blockade of the...