نتایج جستجو برای: neuro endocrine tumours
تعداد نتایج: 93636 فیلتر نتایج به سال:
The theme of this dissertation is the mode of presentation, assessment and management of six patients with tumours of the pituitary gland. Such tumours may be secretory or non-secretory. Typically secretory tumours present with endocrine abnormalities due to hypersecretion of a particular hormone, while nonsecretory tumours present with symptoms caused by the expansion of the lesion in the pitu...
Multiple endocrine neoplasia type 1 (MEN1) is an inherited tumour syndrome characterized by the development of tumours of the parathyroid, anterior pituitary and pancreatic islets, etc. Heterozygous germ line mutations of MEN1 gene are responsible for the onset of MEN1. We investigated the probands and 31 family members from eight unrelated Chinese families associated with MEN1 and identified f...
Introduction In normal conditions FSHR are expressed in the ovary and the testis. It is well known that they can also be expressed in gonadal tumours. However, recently we have found FSHR immunopositivity in tumoral tissues of other endocrine tumours, namely pituitary adenomas, adrenal tumours and neuroendocrine gut and lung tumours (carcinoids). The aim of this study was to see whether the sam...
Oestrogen receptor (ER) expression in breast cancer is regarded as a phenotype that may change during the natural history of the disease or during endocrine therapy. It has been suggested that in up to 70% of tumours that show acquired resistance the mechanism may be changed in ER status from positive to negative. This paper proposes an alternative hypothesis that ER expression in a stable phen...
The preoperative use of systemic therapy for primary breast cancer has the potential to downstage tumours. This would render suitable for breast conservation some tumours that were unsuitable at initial presentation, or would convert some inoperable locally advanced breast cancers into tumours that are operable. No survival benefit has been demonstrated for neoadjuvant chemotherapy compared wit...
Multiple endocrine neoplasia type 1 (MEN1) is an autosomal dominant disorder characterized in man by parathyroid, pancreatic, pituitary and adrenal tumours. The MEN1 gene encodes a 610-amino acid protein (menin) which is a tumour suppressor. To investigate the in vivo role of menin, we developed a mouse model, by deleting Men1 exons 1 and 2 and investigated this for MEN1-associated tumours and ...
Background: Even though tumours are considered to occur frequently in pet hamsters, there is only a small number of scientific reports current literature. Methods: Pathological from 177 hamsters were evaluated. Results: Of these, 78 male and 75 female. Median age affected was 12 months (range 2–34). Integumental the most common neoplasms (62%, 109/177). As far as species known, Syrian (52%, 30/...
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