Mitochondrial dysfunction is a key driver of neurodegeneration. This study aimed to evaluate the protective potential EPOR/CD131 (heterodimeric erythropoietin receptor) stimulation in neurodegeneration caused by rotenone-induced mitochondrial dysfunction. The effects (EPO) and an EPO mimetic peptide pHBSP were assessed using vivo vitro models. Single injections 10 µg/kg or 5 significantly allev...

Vitamin E deficiency is associated with many neurological problems. Although the mechanisms of vitamin action in neurodegenerative diseases are not clear, there possible mechanisms. Examples such protective effects against oxidative stress damage and its suppressive role expression genes involved development neurodegeneration. Many studies have evaluated relationship between intake or levels bo...

Contextual processing (or context processing; CP) is an integral component of cognition. CP allows people to manage their thoughts and actions by adjusting surroundings. involves the formation internal representation in relation environment, maintenance this information over a period time, updating mental representations reflect changes environment. Each these functions can be affected aging as...

Tau is one of several types of microtubule-associated proteins (MAPs), responsible for the assembly and stability of microtubule networks that is present only in neurons and predominantly localized in axons which its functions are tightly regulated by phosphorylation. Via as yet unknown mechanisms, tau becomes hyperphosphorylated and accompanies with neuronal degeneration, loss of synapses...

Several studies suggest that systemic infection occurring during aging and chronic neurodegenerative diseases can evoke an exaggerated immune response that contributes to the progression of neurodegeneration and cognitive decline. However, studies directly addressing the relationship between microbial environment and the onset of neurodegeneration in Alzheimer's disease animal models are lackin...

BACKGROUND Type 2 diabetes mellitus (T2DM) and several types of neurodegeneration, including Alzheimer's, are linked to insulin-resistance, and chronic high dietary fat intake causes T2DM with mild neurodegeneration. Intra-cerebral Streptozotocin, a nitrosamine-related compound, causes neurodegeneration, whereas peripheral treatment causes DM. HYPOTHESIS Limited early exposures to nitrosamine...

Several studies reported that genetic variants predisposing to neurodegeneration were at higher frequencies in centenarians than younger controls, suggesting they might favor also longevity.

Pantothenate-kinase-associated neurodegeneration is the most common autosomal recessive form of neurodegeneration with brain iron accumulation. Less than 100 mutations in PANK2 gene (20p13) are responsible for classic and atypical cases. We report here the first Greek case of atypical pantothenate-kinase-associated neurodegeneration, confirmed by molecular analysis that revealed two trans-actin...

IMPORTANCE Pathophysiologic mechanisms leading to loss of white matter integrity and the temporal positioning of biomarkers of white matter integrity relative to the biomarkers of gray matter neurodegeneration and amyloid load in the course of Alzheimer disease (AD) are poorly understood. OBJECTIVE To investigate the effects of AD-related gray matter neurodegeneration and high β-amyloid on wh...

Multiple Sclerosis (MS) is an autoimmune disease of the central nervous system associated to myelin loss and neurodegeneration. Clinically patients suffer from diverse symptoms and face the risk to become wheelchair-bound. At the moment MS is incurable, thus there is an unmet need for therapeutic options.