We have examined the monomer-polymer equilibria which form the cytoskeletal polymers in squid axoplasm by extracting protein at low concentrations of monomer. The solution conditions inside the axon were matched as closely as possible by the extraction buffer (buffer P) to preserve the types of protein associations that occur in axoplasm. Upon extraction in buffer P, all of the neurofilament pr...

The possibility that proteins are modified during axoplasmic transport in central nervous system axons was examined by analyzing neurofilament proteins (200,000, 140,000, and 70,000 mol wt) along the mouse primary optic pathway (optic nerve and optic tract). The major neurofilament proteins (NFPs) exhibited considerable microheterogeneity. At least three forms of the " 140,000" neurofilament pr...

PURPOSE In response to acute damage, Muller glia in the retina have been shown to dramatically alter their expression of filamentous proteins. Since damaged retinal cells are known to produce growth factors such as insulin-like growth factor (IGF), ciliary neurotrophic factor (CNTF) and fibroblast growth factor (FGF), the altered expression of filaments in Muller glia in response to retinal dam...

This paper examines the role of knowledge management (KM) in not-for-profit organisations (NFPs) using case study methodology and advances previous KM work. NFPs are essential in developing sustainable communities providing many social, environmental, health and human services required by a vast amount of community stakeholders. With limited research related to KM in an NFP setting, this paper ...

The purpose of this study was to describe and assess certified nurse-midwives' (CNMs) knowledge and promotion of two modalities for child spacing, natural family-planning (NFP) and the lactational amenorrhea method (LAM). One thousand two hundred CNMs were randomly selected from a national membership list and mailed a 24-item questionnaire on NFP and LAM. Of the 514 respondents (42.8% return ra...

Organizational performance in most survey-based management control research appears on the “left hand side of the equation” as a dependent variable. The objective typically being to identify, predict or model the effects of management control variables presumed to be causally antecedent. However, the effects of organizational performance acting as an independent variable has received surprising...