The central nervous system (CNS) is among the most important organ systems, integrating information inputs and coordinating the activity of all other body systems. Like many organ systems, the CNS is susceptible to infection by pathogenic microorganisms, including many arboviruses that are considered neurotropic because they are able to achieve robust replication in neural cells. Neurotropic ar...

BACKGROUND/AIMS Changes in the glucocorticoid milieu contribute to alterations in neurotropic factor expression across multiple brain regions. Insulin-resistant diabetes is often accompanied by dysregulation of adrenal steroid production in humans and animal models. Leptin receptor-deficient mice (db/db) show reduced expression of brain-derived neurotropic factor (BDNF) in the hippocampus and i...

Novel approaches attempt to provide an alternative to autologous nerve graft. Nerve guidance conduit (NGC) have been designed to bridge the gap and provides guidance for sprouting axon and provide a place for diffusion of neurotropic factors and endogenous/transplanted cells at the lesion site [2]. It is believed that an ideal nerve conduit should provide not only structural support for damaged...

There are many rumors and mutual accusations between belligerent nations of carrying out studies gain function pathogens with the intention using such as weapons hybrid war. Thus reported A neurotropic H5N1 avian influenza virus (IAV) strain named IAV/WSN /33 (H1N1) that induced conversion PrPC into PrPSc formation infectious prions bring danger a type potential risk for development to warfare ...

Chikungunya most often is a self-limiting febrile illness with polyarthritis and the virus is not known to be neurotropic. We are reporting a case of chikugunya fever presenting as acute demyelinating encephalomyelitis(ADEM) which is very rare.

Measles virus-infected hamster brain tissue remained viable when frozen slowly in medium containing dimethyl sulfoxide. This procedure was essential for isolation of neurotropic measles virus from tissue specimens stored frozen.

Herpes simplex virus 1 (HSV-1), also known as Human herpesvirus 1, is a highly prevalent human neurotropic pathogen that causes a variety of diseases, including lethal encephalitis. Here, we report the genome sequence of the HSV-1 strain SC16.

The central nervous system (CNS) harbors highly differentiated cells, such as neurons that are essential to coordinate the functions of complex organisms. This organ is partly protected by the blood-brain barrier (BBB) from toxic substances and pathogens carried in the bloodstream. Yet, neurotropic viruses can reach the CNS either by crossing the BBB after viremia, or by exploiting motile infec...