diagnosis of subclinical and early stage clinical periodontal dysfunction could prevent from further socioeconomic burden. the aim of this study was to assess the diagnostic applicability of nitric oxide and its end-metabolites in periodontal tissue health and disease. forty-two patients were enrolled and divided into three groups according to gingivitis (gi) and clinical attachment level (cal)...

Introduction: Some studies have demonstrated the potential of herbal drugs for the treatment of various diseases associated with impaired vascular nitric oxide (NO). For diagnosis of the mechanism of these herbal plants, it seems necessary to evaluate the herbal extracts on the Endothelium cell. The aim of the study was to investigate the effect of extract of Trigonella foenum-graecum (T.foenum...

BACKGROUND Nitric oxide (NO*) plays a pivotal role as a leishmanicidal agent in mouse macrophages. NO* resistant Escherichia coli and Mycobacterium tuberculosis have been associated with a severe outcome of these diseases. METHODS In this study we evaluated the in vitro toxicity of nitric oxide for the promastigote stages of Leishmania (Viannia) braziliensis and Leishmania (Leishmania) amazon...

Nitric oxide (NO) is believed to be involved in the pathophysiology of sepsis. This study evaluated the activity of the NO pathway in a human endotoxin model. At baseline and after endotoxin, on-line measurements of exhaled NO (eNO) were made using a chemiluminescence technique with a single-breath method. NO-free air was inhaled prior to exhalation against a resistance. NO in orally and nasall...

Background: Defective sperm quality is a significant cause of infertility in men. It is known that nitric oxide (NO) is a highly reactive free radical gas which has a dual function, being both a cytotoxic and necessary molecule for normal sperm production. Materials and Methods: To investigate correlation between NO levels with sperm parameters, a case-control study were designed with total of ...

The development of cancer cell resistance to various cytotoxic stimuli continues to be a major challenge in oncology and novel therapeutic approaches are urgently needed. Nitric oxide (NO) is emerging as a potential anti-oncogenic agent to overcome tumor cell resistance to conventional therapeutic agents. NO is a ubiquitous, water-soluble, free radical gas that exerts a wide range of biological...

With respect to the ambient nitric oxide values, we have examined their effect on exhaled nitric oxide. Since there was no significant influence of ambient nitric oxide levels ,20 ppb on the fraction of exhaled nitric oxide values in our study population (figs 2 and 3), we decided to include all children with ambient nitric oxide levels ,20 ppb in the analyses. When the analyses were repeated, ...

Adenosine is a putative endogenous sleep-inducing substance, and nitric oxide has been implicated in arousal and sleep mechanisms. We found that various nitric oxide donors, including diethylamine NONOate (DEA/NO), stimulated large increases in extracellular adenosine in nearly pure cultures of forebrain neurons. The effect of DEA/NO could be blocked by 2-phenyl-4,4,5, 5-tetramethyl-imidazoline...

background: respiratory distress syndrome and persistent pulmonary hypertension of the newborn are common acquired diseases in preterm infants. in the past several years, randomized controlled trials (rcts) have indicated that inhaled nitric oxide (ino) can potentially lower for both the incidence of bronchopulmonary dysplasia (bpd) and mortality in affected infants. other research has, however...