An increase in extended-spectrum-lactamase (ESBL)-producing Escherichia coli has been observed in outpatient settings. Consequently, 100 ESBL-positive E. coli isolates from ambulatory patients with clinically confirmed urinary tract infections were collected by a single laboratory between October 2004 and January 2008. Antimicrobial susceptibility testing was carried out using the oral antibiot...

INTRODUCTION The objective of this study was to provide an update on the resistance of Escherichia coli in women with acute uncomplicated urinary tract infections (UTIs) in France, Germany, Spain, Sweden, and the United Kingdom (UK) to mecillinam [amdinocillin (United States Adopted Name)], amoxicillin-clavulanic acid, cefadroxil, nitrofurantoin, ciprofloxacin, and trimethoprim, and to compare ...

Severe intrahepatic cholestasis occurred in a patient after taking nitrofurantoin, ampicillin, and cloxacillin. As only nitrofurantoin was known to cause cholestasis she was given cloxacillin again two years later. The cholestasis reappeared at once. A macrophage inhibition factor test confirmed that cloxacillin was the offending drug. Cloxacillin should be added to the growing list of drugs ca...

In 2007 the Netherlands Pharmacovigilance Centre Lareb sent an signal to the Medicines Evaluation Board (MEB) concerning four reports of cutaneous vasculitis associated with nitrofurantoin [1]. These reports were received by Lareb in the period from September 1997 to October 2006. Since then, Lareb received three additional reports of vasculitis associated with the use of nitrofurantoin. The cu...

Drug-induced interstitial lung disease is a rare condition attributed to several medications, including antimicrobial agents such as amphotericin B, anti-inflammatory agents such as methotrexate, biologic agents such as bevacizumab, and cardiovascular agents and chemotherapeutic agents. We describe the case of a 73-year-old female who developed interstitial lung disease following chronic use of...

BACKGROUND The prevalence of antimicrobial resistance among uropathogenic E. coli varies widely worldwide; to guide empirical therapy is necessary to have local, up-to-date susceptibility data. METHODOLOGY We tested 907 isolates from patients in Mexico City by disk diffusion and further characterized ciprofloxacin, cephalosporin and nitrofurantoin resistant strains. RESULTS Isolates were mo...

Drug induced liver injury is a recognised cause of acute liver failure. A wide range of drugs have been implicated, of which the most common are Paracetamol and antibiotics. Nitrofurantoin is a commonly prescribed antimicrobial which may cause liver injury from either acute or chronic exposure. This complication was thought to occur with an extremely low incidence; however recent data suggests ...