A novel form of mixed-linker ZIF with the RHO topology is one of four zinc-imidazolate frameworks prepared with purine and 2-nitroimidazole. In this structure the linkers order to give a large pore solid with a high pore volume and an unusual symmetry and linker orientation. It possesses extra-framework zinc imidazolate units decorating the internal surface which can be removed to give high por...

1. Is it possible that, by using Ronidazole (E-759) in the feedingstuffs for turkeys, according to the conditions set up by Council Directive 70/524/EEC (1) (See background), residues with the intact nitroimidazole structures may still be present, beyond the six-day pre slaughter withdrawal period? 2. In view of (1) above, may the consumer be exposed to these residues ? and would these residues...

Plasma concentrations of lignocaine and the clearance rates of technetium-99m were compared in 10 healthy volunteers after injection with a gas-powered jet system and a needle and syringe. The dosage was highly accurate with jet injection. Bioavailability was comparable for both methods.

Reaction of substituted-aniline (8) with ethyl (l-methyl-5-nitroimidazole-2- carbonyl) acetate (9) gave 4-hydroxy-2-(l-methyl-5-nitro-2-imidazolyl)- substituted-quinolines (lo), which were converted to compound 11 with phosphorus oxychloride. Substituted-2-(l-methyl-5-nitro-2-imidazo1yl)-4.- methyl-(or phenyl-) quinolines (14) were prepared through the reaction of 2- acetyl-5-nitro-1-methy...

We developed a 1,3-dipolar cycloaddition reaction of azomethine imines with terminal alkynes catalyzed by group 11 metal amides to provide N,N-bicyclic pyrazolidinone derivatives. This reaction afforded the cycloadducts in a unique 5,7-disubstituted manner. Furthermore, we succeeded in applying this catalysis to asymmetric reactions, and the desired heterocycles were produced in high yields wit...

A simple and mild process was developed for the highly stereoselective synthesis of halogenated bicyclic [4.3.0] and [3.3.0] γ-lactams, possessing four stereocenters, from easily available cyclic 2-enynamides. The reaction required only an inexpensive iron(II) halide under dry air and was tolerant of aryl, heteroaryl, and alkyl groups at the alkyne terminus.