BACKGROUND We present survival outcomes of patients registered in the Dutch population-based Eindhoven Cancer Registry (ECR). PATIENTS AND METHODS Data on patients diagnosed with a melanoma between 1980 and 2002 were obtained from the ECR. Data on vital status up to 1 January 2005 were obtained, up-to-date survival rates were calculated using period analysis. Multivariate analyses were carrie...

AIM To determine prognostic factors for recurrence of disease and tumour related mortality in patients with conjunctival melanoma. METHODS A retrospective analysis of clinical and histopathological data of 69 patients with histologically verified conjunctival melanoma. RESULTS As univariate analysis showed, significant risk factors for the development of recurrence were: irregular pigmentat...

absract intracranial invasion of cellular blue nevus (cbn) from the skin is extremely rare and such a condition with malignant transformation is even rarer. a case of meningeal melanoma with malignant transformation which was derived from an ota nevus is presented in this report. a21-year-old man with a neurocutaneous syndrome since childhood was referred with headache and mild left hemiparesia...

Melanoma is accounted as a rare skin cancer responsible for huge mortality rate. However, various imaging tests can be used to detect the metastatic spread of disease with primary diagnosis or on clinical suspicion. Focus melanoma detection, irrespective its unusual occurrence, that it often misdiagnosed other malignancies leading medical negligence. Sometimes detected only when metastasis has ...

Backgrounds: Genetic alterations are strongly involved in carcinogenesis and pathogenesis of melanoma. Although non-acral cutaneous melanoma has been fully analyzed, acral mucosal need more investigation. Somatic copy number variation (CNV) is one the major genetic melanomas. Previous studies have suggested that CNV due to instability caused early palmoplantar melanoma, however it not yet evalu...

BACKGROUND/AIM Melanoma is a heterogeneous disease of skin and mucous membranes which shows significant increase in incidence worldwide in the past decades. In the process of forming new blood vessels stimulators of angiogenesis participate. There is an increase production of vascular endothelial growth factor (VEGF-C and VEGF-D), which expression cause change of endothelial cells, and higher d...

BACKGROUND With melanoma incidence rising and mortality stable, some question whether the melanoma epidemic is real. Melanoma thickness and survival trends may provide insights, but previous studies have been limited because of missing data on thickness. METHODS With a validated imputation method for missing thickness data, we characterized melanoma thickness and survival trends among men and...

We report here a rare case of metastatic malignant melanoma presenting as ileo-ileal intussusception. A 66-year-old man revealed a past medical history of excision of malignant melanoma, followed by axillary lymph node spread treated with block dissection and radiotherapy. He presented with symptoms of small bowel obstruction and subsequent CT revealed a likely nodular intussusception. Resectio...

Introduction. Cutaneous foot melanoma is rare, challenging to manage, and not adequately examined in the literature. This study evaluated the prognostic variables and surgical management of foot melanoma. Materials and Methods. Foot melanoma cases managed at an academic center from 1985 to 2010 were retrospectively reviewed. Results. 46 patients were identified with a broad range of demographic...