The aim of this study is to formulate a novel ophthalmic nanosuspension (ONS), an alternative carrier system to traditional colloidal carriers for controlled release (CR) of acyclovir (ACV). In the present study, ONS is employed to avoid some of major disadvantages of colloidal carriers systems such as instability in cul de sac and short half life by increasing efficiency of drug encapsulation ...

Enzymatically crossliked gelatin hydrogel was submitted to two different drying methods: air drying and freeze drying. The resulting polymeric tridimensional arrangement (compact or porous, respectively) led to different thermal and swelling properties. Significant differences (p < 0.05) on thermal and mechanical characteristics as well as swelling in non-enzymatic gastric and intestinal simula...

Buccoadhesive buccal delivery systems for losartan potassium in the form of buccal films were developed and characterized for improving bioavailability. The films were formulated by solvent casting method using different bioadhesive polymers like HPMC, Eudragit RS100, Eudragit RL100 and Ethylcellulose with glycerol as plasticizer. The films were characterized on the basis of their physical char...

The aim of the present research was to prepare and evaluate a gastroretentive drug delivery system for metformin HCl, using synthetic and semi-synthetic polymers. The floating approach was applied for preparing gastroretentive tablets (GRT) and these tablets were manufactured by the direct compression method. The drug delivery system comprises of synthetic and semi-synthetic polymers such as po...

The objective of the present research was to develop a bilayer tablet of propranolol hydrochloride using superdisintegrant sodium starch glycolate for the fast release layer and water immiscible polymers such as ethylcellulose, Eudragit RLPO and Eudragit RSPO for the sustaining layer. In vitro dissolution studies were carried out in a USP 24 apparatus I. The formulations gave an initial burst e...

The purpose of the present research work was to observe the effects of drug solubility on their release kinetics of water soluble verpamil hydrochloride and insoluble aceclofenac from hydrophilic polymer based matrix formulations. Matrix formulations were prepared by the direct compression method. The formulations were evaluated for various physical parameters. Along with the dynamics of water ...

The study was aimed isolate tamarind seed polysaccharide from tamarind kernel powder, crosslinking of isolated polysaccharide with epichlorohydrin and to assess the release behaviour of drugs, diclofenac sodium and ketoprofen from isolated tamarind seed polysaccharide and cross linked tamarind seed polysaccharide as release retardant. The presence of polysaccharide was confirmed by phytochemica...

We performed fluorescence correlation spectroscopy measurements to assess the long-time self-diffusion of a variety of spherical tracer particles in periodic porous nanostructures. Inverse opal structures with variable cavity sizes and openings in the nanometer domain were employed as the model system. We obtained both the exponent of the scaling relation between mean-square displacement and ti...

Drug release from a swelling hydrogel matrix is a complicated process where diffusion of drug molecules is coupled to the swelling kinetics. The swelling influences the diffusional flux of drug molecules by increasing the diffusion coefficient and diffusional pathlength. Release of phenylpropanolamine from apoly(hydroxyethy1 methacrylate-co-methacrylic acid) hydrogel, initially at low pH, is hi...

Regional-scale groundwater quality degradation from nonpoint source pollution threatens the long-term sustainability of major alluvial aquifer-aquitard systems worldwide. Models are needed to simulate regionally upscaled transport processes in heterogeneous geology that produces non-Fickian (anomalous) transport. In this investigation, we show impact nonhorizontal and nonvertical mean flow dire...