Fragile X syndrome is an X-linked mental retardation condition that usually is due to a trinucleotide-repeat expansion in the FMR1 gene. Whereas full-mutation alleles (> 230 repeats) lead to fragile X syndrome, premutation alleles (approximately 60-200 repeats) are apparently non-penetrant. However, previous studies have suggested that female premutation carriers may have an increased incidence...

This paper addresses the global outer synchronization problem between two fractional-order complex networks coupled in a drive-response configuration. In particular, for a given fractional-order complex network composed of Lur’e systems, an observer-type response network with non-fragile output feedback controllers is constructed. Both additive and multiplicative uncertainties that perturb the ...

Over the last several years, evidence has accumulated that the GABAA receptor is compromised in animal models for fragile X syndrome (FXS), a common hereditary form of intellectual disability. In mouse and fly models, agonists of the GABAA receptor were able to rescue specific consequences of the fragile X mutation. Here, we imaged and quantified GABAA receptors in vivo in brain of fragile X pa...

In this paper symbolic quantifier elimination methods are used to explore the fragility of feedback compensators, and to design feedback systems with non-fragile compensators. A compensator is said to be fragile if given variations in compensator parameters result in significant deterioration of feedback performance. The issue of fragility is important in understanding the level of acurracy req...

This paper investigates the problem of non-fragile observer-based passive control for descriptor systems with time-delay. The perturbations in both the control gain and observer gain of the observer-based controller are considered. For the cases of the additive perturbations and multiplicative perturbations, sufficient conditions are given such that the closed-loop systems are admissible and pa...

In this paper, we address global non-fragile control and synchronization of a new fractional order chaotic system. First we inspect the chaotic behavior of the fractional order system under study and also find the lowest order (2.49) for the introduced dynamics to remain chaotic. Then, a necessary and sufficient condition which can be easily extended to other fractional-order systems is propose...

Article history: Received 15 August 2006 Received in revised form 7 August 2008 Accepted 19 August 2008

This paper investigates the problem of non-fragile controller design for Takagi-Sugeno fuzzy systems with norm-bounded time-varying parametric uncertainties and distributed delays. The controller to be designed is assumed to have time-varying norm-bounded uncertainties in the additive form. A sufficient condition in terms of linear matrix inequalities is derived, which guarantees the robust asy...

This paper describes a robust and non-fragile H∞ controller design method for descriptor systems with parameter uncertainties and time delay, as well as a static state feedback controller with multiplicative uncertainty. The controller existence condition, as well as its design method, and the measure of non-fragility in the controller are proposed using linear matrix inequality (LMI) technique...