PURPOSE To determine the optimal number of biopsies in patients with non-obstructive azoospermia (NOA) who undergo testicular sperm extraction (TESE), and assess the impact of testicular histology on outcome. MATERIALS AND METHODS Seven hundred and forty-one patients with NOA who underwent TESE in our institution were enrolled in the study. Testicular sperm extraction was performed applying a...

Objective: To analyze the causes, clinical features and t r ea tment ou tcomes in pa t i en t s w i th nonobstructive azoospermia (NOA) and different severity of hypospermatogenesis (HS). Methods: This is a retrospective study from our reproductive clinic. Data of history, physical findings, serum hormone profiles and genetic studies were collected. The severity of HS was subdivided into three ...

From 1 August 1993 until 30 September 1994, 69 couples suffering from azoospermia underwent testicular sperm extraction and intracytoplasmic sperm injection. In 50 couples with obstructive azoospermia a total of 631 metaphase-II oocytes were injected after testicular sperm extraction yielding a 2-PN fertilization rate of 57%. In female patients <40 years of age an ongoing pregnancy rate per tra...

Objective: To investigate the of epididymal width in identifying non obstructive azoospermia (NOA) and obstructive azoospermia (OA). Methods: Using scrotal ultrasound to compare difference of epididymal width between OA (n=18) and NOA (n=10) patients. Results: In the patients with OA average bilateral epididymal width is 0.7+0.1 cm, which is higher than the NOA patients (P<0.05) by ultrasonic m...

Background: About 15% of couples worldwide suffer from infertility problem that half of these cases are related to male infertility. Spermatogenesis is a cumulative process and thousands of genes are involved in it. Change in one of these genes or their products can cause male infertility. Tex11 is a germ cell specific gene that is located on the X chromosome (Xq13.1 region). This gene was iden...

Assisted reproduction with testicular sperm extraction (TESE) and intra-cytoplasmic sperm injection (ICSI) are fertility treatment options for couples with severe oligospermia or azoospermia. A retrospective review was performed of 146 TESE procedures in a specialist fertility centre in Ireland. The indication for TESE was obstructive azoospermia (OA) in 59% (n = 80) and non-obstructive azoospe...

Obstructive azoospermia (OA) is defined as the absence of spermatozoa in the ejaculate despite normal spermatogenesis, but either a mechanical blockage exists in the genital tract between the epididymis and the ejaculatory duct or the vasa deferentia are absent. A normal testicular biopsy is pathognomonic for obstruction, and a vasography should be indicated to identify the site of the obstruct...

Today, approximately 15% of couples have reduced fertility. In most cases the reason is male infertility, usually of genetic origin. Thus, in the context of research in genes involved in reproduction and sex determination, genetic defects in gametogenesis are being extensively studied. The most frequent pathogenic causes of male infertility are Y chromosomal microdeletions and obstructive azoos...

INTRODUCTION Main categorisation of azospermic is in two grups: nonobstructive azoospermia (NOA) and obstructive azoospermia (OA). We had evaluation of prognostic factors and determinants in sperm retrieval procedures in azoospermic patients. METHODS Retrospective evaluation observed 21 selected patients with NOA and OA azoospermia, after that complete history, physical examination with ultar...