Objective: To investigate the effect of acute normovolemic hemodilution (ANH) combined with controlled hypotension (CH) on extravascular lung water and systematic oxygen metabolism for elderly patients, and to explore the clinical security of ANH + CH. Methods: 45 elderly patients undergoing elective spine and hip replacement surgery were selected and randomly divided into 3 groups (n=15 in eac...

Poor condition subarachnoid hemorrhage (SAH) patients present a high mortality and morbidity. In this study, we reviewed the acute interventional (surgical and endovascular) management of 109 SAH-poor condition patients, who were treated as early as logistically possible after confirming stable circulation parameters. Patients over the age of 70 years, without clinical response to painful stimu...

BACKGROUND AND PURPOSE Hemodilution in the acute phase of ischemic stroke is still controversial. Multicenter studies have failed to demonstrate any benefit. The present study focuses attention on analysis of circulation in stroke and on individual restabilization of circulation. METHODS The Amsterdam Stroke Study is a prospective, single-center, randomized clinical trial (n = 300). Normovole...

The aim of this study was to test the influence of oxygen affinity of Hb vesicles (HbVs) and level of blood exchange on the oxygenation in collateralized, ischemic, and hypoxic hamster flap tissue during normovolemic hemodilution. Microhemodynamics were investigated with intravital microscopy. Tissue Po2 was measured with Clark-type microprobes. HbVs with a P50 of 15 mmHg (HbV15) and 30 mmHg (H...

BACKGROUND AND OBJECTIVES There is a need for simple method allowing detection of dehydration and hypovolemia. Based on a new theory of homeostatic blood states, we hypothesized that hemodilution following standardized crystalloid fluid bolus can be used to discriminate between baseline normohydration and dehydration, also normovolemia and hypovolemia. METHODS Computer simulations based on pr...

Isovolemic hemodilution does not appear to impair CO2 elimination nor cause CO2 retention despite the important role of red blood cells in blood CO2 transport. We studied this phenomenon and its physiological basis in eight New Zealand White rabbits that were anesthetized, paralyzed, and mechanically ventilated at a fixed minute ventilation. Isovolemic anemia was induced by simultaneous blood w...

Rigorous control procedures adopted presently by blood banks have reduced transfusionassociated risks, such as transmission of infectious diseases. Nevertheless, other complications related with blood-transfusions remain, such as transfusion-related acute lung injury (TRALI) and other immune disorders. In critically ill patients, transfusion has been associated with increase in morbidity and mo...