One of the most frequent comorbidities of HIV infection is depression, with a lifetime prevalence of 22 to 45%. Therefore, it was decided to study a potential pharmacokinetic interaction between the nonnucleoside reverse transcriptase inhibitor nevirapine (NVP) and the tricyclic antidepressant nortriptyline (NT). NVP and NT were administered to rats either orally, intraduodenally, or intravenou...

Twelve patients acted successfully as subjects to study what effect if any the benzodiazepines nitrazepam, diazepam, oxazepam, and chlordiazepoxide might have on steady-state plasma levels of nortriptyline and amitriptyline. No significant detectable effect was discovered. In view of the known interaction effects of other alternative tranquillizing drugs and hypnotics it seems reasonable to cho...

Background: Some studies have found a curvilinear relationship between the nortriptyline plasma concentration and the clinical rating of depression in those treated. The concentration interval of optimum response has been called the “nortriptyline therapeutic window.” Objectives: To analyze all original data relevant to the therapeutic window. Data sources: English language articles found in Pu...

AIMS To characterize the nonspecific binding to human liver microsomes of drugs with varying physicochemical characteristics, and to develop a model for the effect of nonspecific binding on the in vitro kinetics of drug metabolism enzymes. METHODS The extent of nonspecific binding to human liver microsomes of the acidic drugs caffeine, naproxen, tolbutamide and phenytoin, and of the basic dru...

GENERIC NAME PAGE Amitriptyline 389 Amoxapine 389 Bupropion 388 Carbamazepine 395 Citalopram 388 Clomipramine 389 Desipramine 389 Doxepin 389 Fluoxetine 387 Fluvoxamine 386 Imipramine 389 Isocarboxazid 392 Lithium 393 Maprotiline 389 GENERIC NAME PAGE Mirtazapine 388 Nefazodone 389 Nortriptyline 389 Olanzapine 395 Paroxetine 388 Phenelzine 392 Protriptyline 389 Sertraline 387 Tranylcypromine 39...