Vascular diseases are the most prevalent diseases worldwide. This study intended to analyze peripheral blood miRNA levels and their correlation with NT-pro-BNP and cTN-I in patients with atherosclerosis or pre-atherosclerotic conditions to build a dynamic correlation between vascular diseases and their biomarkers. Serum NT-pro-BNP and cTN-I levels were measured by their respective ELISA kits. T...

BACKGROUND Atrial fibrillation (AF) is the most common arrhythmia encountered in clinical practice. Elective electrical cardioversion is often performed in patients with persistent AF to attempt sinus rhythm (SR) restoration. However, AF recurrences are frequent after successful cardioversion and several predictors have been identified. AIM OF THE STUDY The present study was designed to prosp...

†Departments of Paediatrics, ‡Medicine, §Chemical Pathology, College of Medicine, University of Lagos, Nigeria. *Correspondence: E. N. Ekure, Departments of Paediatrics, College of Medicine, University of Lagos, Nigeria. Email addresses: ENE: [email protected] CAN: [email protected] JNA: [email protected] AM: [email protected] JO: [email protected] Abbreviations: CHF, Congestive...

BACKGROUND NT pro-BNP is a marker of systolic and diastolic dysfunction. OBJECTIVE To determine NT pro-BNP levels in patients with chagasic, hypertrophic, and restrictive heart diseases, as well as with pericardial diseases, and their relation to echocardiographic measurements of systolic and diastolic dysfunction. METHODS A total of 145 patients were divided into the following groups: 1) C...

Detecting left ventricular (LV) dysfunction at an early stage is key in addressing the heart failure epidemic. In proteome profiling experiments in mice subjected either to aortic banding or sham, the circulating CXCR3 ligands monokine induced by interferon-γ (MIG) and interferon-γ inducible protein 10 (IP10) were 5 to 40 fold up-regulated at eight weeks. We assessed the diagnostic value of cir...

Patients with idiopathic pulmonary arterial hypertension usually undergo acute vasodilator tests with nitric oxide (NO) for haemodynamic evaluation and therapeutical planning. The aim of this study was to evaluate the link between the variation of N-terminal (NT)-pro-brain natriuretic peptide (BNP) levels and haemodynamic parameters during the acute vasodilator test. A total of 22 idiopathic pu...

AIM to evaluate whether pro BNP can be used for detection of diastolic dysfunction. METHODS thirty nine hypertensive patients with normal systolic function, consecutively referred for echocardiography examination between October and December 2004 were recruited in the study. Diastolic dysfunction was diagnosed when echocardiographic mitral flow pattern demonstrated impaired relaxation, pseudo...

AIM The relationship between fibroblast growth factor 21 (FGF21) and cardiovascular disease has been well established in recent studies. This study aimed to investigate the relationship between FGF21 and left ventricular systolic dysfunction and cardiac death. METHODS Two-dimensional echocardiography was used to measure the left ventricular ejection fraction (LVEF) to estimate left ventricula...