We have demonstrated that T3 increases the expression of ZAKI-4alpha, an endogenous calcineurin inhibitor. In this study we characterized a T3-dependent signaling cascade leading to ZAKI-4alpha expression in human skin fibroblasts. We found that T3-dependent increase in ZAKI-4alpha was greatly attenuated by rapamycin, a specific inhibitor of a protein kinase, mammalian target of rapamycin (mTOR...

Ca(2+)/calmodulin-regulated protein kinase II (CaMKII) mediates many cellular events. The four CaMKII isoforms have numerous splice variants, three of which contain nuclear localization signals. Little is known about the role of nuclear localized CaMKII in neuronal development. To study this process, PC12 cells were transfected to produce CaMKII targeted to either the cytoplasm or the nucleus a...

Fast and accurate transient response is the main requirement in electric machine position control. Conventional cascade control structure has sluggish response due to the limitation of inner control loop bandwidth. In this paper, in order to decrease the Permanent Magnet Synchronous Motor (PMSM) transient response time it can be used reference model using feed-forward signals. In this structure...

The ball and beam system is one of the most popular laboratory setups for control education. In this paper, we design a fuzzy PD cascade controller for a ball and beam system using Asexual Reproduction Optimization (ARO) technique. The ball & beam system consists of a servo motor, a grooved beam, and a rolling ball. This system utilizes a servo motor to control ball’s position on the beam. Chan...

In this paper, the problems of control and stabilization of switched nonlinear cascade systems is investigated. The so called simultaneous domination limitation (SDL) is introduced in previous works to assure the existence of a common quadratic Lyapunov function (CQLF) for switched nonlinear cascade systems. According to this idea, if all subsystems of a switched system satisfy the SDL, a CQLF ...

during the last years the total cost of lng technology has decreased significantly due to improvements of the liquefaction process. however, many liquefaction plants that are still in operation use a three-cascade refrigeration system. in this paper, an advanced exergetic analysis is applied to better understand the operation of a three-cascade refrigeration system for liquefaction of natural g...

proton exchange membrane fuel cells (pemfcs) with a dead-ended anode and cathode can obtain high hydrogen and oxygen utilization by a comparatively simple system. nevertheless, the accumulation of the water in the anode and cathode channels might cause a local fuel starvation degrading the performance and durability of pemfcs. in this study, a brand new design for a polymer electrolyte membrane...

Activation of the MEK/ERK/Elk-signaling cascade is a mechanism for relaying mitogenic and stress stimuli for gene activation. MEK1 is the proximate kinase for activation of ERK1/2, and nuclear targeting of ERK1/2 is obligatory for Elk1 transcriptional activity. Human biliverdin reductase (hBVR) is a recently described Ser/Thr/Tyr kinase in the MAPK insulin/insulin-like growth factor 1 (IGF1)-si...

This review presents the current state of knowledge regarding use radioactive sources to generate photonic light in scintillators as converters ionizing radiation electricity photovoltaic cells. The possibility using phenomenon excitation photons scintillation materials during interaction with particles and was analyzed detail. obtained such a way can an electric charge whole process be named n...

We investigate the feasibility of a high statistics experiment to search for invisible decay modes in nuclear gamma cascades using 200 kg %36 Cs(Tl) scintillators that are presently available at Texas A\&M. The aims missing energy by robustly establishing absence photon well identified cascade. report on experimental demonstration resolution necessary this search. Prior explorations detector co...