نتایج جستجو برای: nuclear shape
تعداد نتایج: 424509 فیلتر نتایج به سال:
• InShaDe is a shape processing framework for visual exploration of cellular and nuclear shapes. The based on descriptor closed contours in 2D surfaces 3D. discrete curvatures, elliptic Fourier analysis sparse coding. 3D pipeline decomposition mean curvatures through Spherical Harmonics. can be used histology images serial section EM data. We present envelopes extracted from microscopic arising...
During intrinsically asymmetric division, the spindle is oriented onto a polarized axis specified by a group of conserved PAR proteins. Extrinsic geometric asymmetry generated by cell shape also affects spindle orientation in some systems, but how intrinsic and extrinsic mechanisms coexist without interfering with each other is unknown. In some asymmetrically dividing cells of the wild-type Cae...
Hutchinson-Gilford progeria syndrome (HGPS) is a premature aging disorder, commonly caused by a point mutation in the lamin A gene that results in a protein lacking 50 aa near the C terminus, denoted LADelta50. Here we show by light and electron microscopy that HGPS is associated with significant changes in nuclear shape, including lobulation of the nuclear envelope, thickening of the nuclear l...
Improved early detection of neoplasia by screening of urothelial cells requires an understanding of the features distinguishing normal and neoplastic cell populations. We have begun a program of study based upon a rat model system for the controlled observation of early-stage lesions produced by the carcinogen N-butyl-N-(4-hydroxybutyl)- nitrosamine. Cells dissociated directly from normal and m...
In fission yeast Schizosaccharomyces pombe, the nuclear envelope remains intact throughout mitosis and undergoes a series of symmetrical morphological changes when the spindle pole bodies (SPBs), embedded in the nuclear envelope, are pushed apart by elongating spindle microtubules. These symmetrical membrane shape transformations do not correspond to the shape behavior of an analogous system ba...
Physicochemical mechanotransduction alters nuclear shape and mechanics via heterochromatin formation
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