Abstract: The microstructural features of the early stage of ordering of the intermetallic compound Pt2FeCu have been examined using optical and transmission electron microscopy in conjunction with X-ray diffraction technique. It was found that the compound has similar morphological alteration to that of FePt in which the ordering cannot be suppressed by rapid quenching. The early stage of ...

A Malaysian family with congenital insensitivity to pain with anhydrosis was diagnosed based on clinical symptoms of chronic ulcers, joint deformities, malunited fractures, anhydrosis, and learning disabilities. We detected a compound heterozygous mutation in exon 16: V709L from the mother and G718S from the father. Two novel mutations were identified: at amino acid 709, a change of G to C at n...

background immunomodulators and nucleotide analogues have been used globally for the dealing of chronic hepatitis b virus (hbv) infection. however, the development of drug resistance is a major limitation to their long-term effectiveness. objectives the aim of this study was to characterize the hepatitis b virus reverse transcriptase (rt) protein variations among iranian chronic hbv carriers wh...

A series of pro-nucleotide phosphoramidates and phosphorodiamidates of the antiviral lead compound 3'-deoxy-3'-fluorothymidine (FLT) have been designed and synthesized. In vitro antiretroviral and cytostatic studies revealed potent (sub-micromolar) inhibition of HIV-1 and HIV-2 replication, with retention of activity in thymidine kinase-negative cell models, as predicted by the ProTide concept.

Uridine diphosphoacetylmuramyl peptide compounds were first isolated from penicillin-treated Staphylococcus aureus, in which they accumulate (1). The major compound that accumulates in this circumstance contains five amino acids and is represented as UDP-Glu’.lc-lactyl-L-Ala-n-Glu-L-Lys-o-;llan-Ala1 (l-3). This compound is believed to be a precursor of the cell wall, which contains, among other...

We have previously described a novel class of nonnucleoside reverse transcriptase (RT) inhibitors, the pyrrolobenzoxazepinone (PBO) and the pyridopyrrolooxazepinone (PPO) derivatives, which were effective inhibitors of human immunodeficiency virus type 1 (HIV-1) RT, either wild type or carrying known drug resistance mutations (G. Campiani et al., J. Med. Chem. 42:4462-4470, 1999). The lead comp...

PURPOSE ACHROMATOPSIA RESULTS FROM MUTATIONS IN ONE OF THREE GENES: cyclic nucleotide-gated channel, alpha-3 (CNGA3); cyclic nucleotide-gated channel, beta-3 (CNGB3); and guanine nucleotide-binding protein, alpha-transducing activity polypeptide 2 (GNAT2). We report the responsible mutations in two United Arab Emirates families who have this autosomal recessive disease. METHODS Clinical exami...

GSAO (4-(N-(S-glutathionylacetyl)amino) phenylarsonous acid) is a novel organoarsenical compound presently completing phase I trials in cancer patients who are refractory to treatment. GSAO targets the mitochondria of proliferating endothelial cells by binding to calcium-replete adenine nucleotide translocase on the inner mitochondrial membrane. Consequently, small solutes equilibrate across th...

Improving the efficiency of drug discovery remains a major focus for the pharmaceutical industry. Toxicity accounts for 90% of withdrawals and major early-stage terminations relate to suboptimal efficacy and safety. Traditional oral drug space is well defined with respect to physicochemical properties and ADMET risks but increased focus on ligand-lipophilicity efficiency, maximizing enthalpy co...