Introduction: 17β-estradiol modulates nociception by binding to estrogenic receptors and also by allosteric interaction with other membrane-bound receptors like glutamate and GABAA receptors. Beside its autonomic functions, paragigantocellularis lateralis (LPGi) nucleus is also involved in pain modulation. The aim of the current study was to investigate the role of the intracellular estrogen...

purpose: to present a patient with localized corneal edema due to a small retained fragment of nucleus in the anterior chamber after uncomplicated phacoemulsification. case report: a 74-year-old female subject with history of phacoemulsification in her right eye about 1.5 years ago complained of foreign body sensation, pain and decreased vision in the same eye. visual acuity of that eye had dec...

As one of the most important diffused brain modulatory systems, the nucleus locus coeruleus (LC) receives most of its afferents from the nucleus paragigantocellularis (PGi) and plays a major role in the control of drug dependence and some emotional and exciting states. For detailed investigation of the effect of morphine on relationship between these two brain stem nuclei, the activity of the r...

Recent neuroanatomical and behavioral evidence has indicated that vasopressin (VA) increases pain threshold. The dorsal raphe nucleus (DRN) is an important nucleus in pain modulation. Anatomical studies have shown that DRN receives vasopressinergic fibers originating in the hypothalamic paraventricular nucleus. The aim of the present study was to examine the effects of intra-DRN injection of de...

Introduction: Oxytocin is a active neuropeptide of central nervous system. In this study the effects of naloxone (opioid receptor antagonist) and yohimbine (α-2 adrenergic receptor antagonist) on analgesic effect of oxytocin applied into the locus coeruleus (LC) nucleus were investigated. Methods: Adult male Wistar rats were used. Animals divided into different groups receiving saline, oxy...

The herpes simplex virus type 1 (HSV-1) tegument protein, VP22 has been reported to have the property of intercellular transport. The previous studies have shown that following expression of a fusion protein containing VP22 it spreads to every cell in a monolayer and concentrates in the nucleus. In spite of these reports, some studies have shown that VP22 trafficking and its nucleus accumulatio...

Background: Mediodorsal (MD) thalamic nucleus, which is considered to take place between extra pyramidal and limbic feedback circuit, receives projective fibers from ventrolateral neurons of reticular part of substantia nigra (SNr). In order to better understand the influence and chemical reaction of these fibers upon MD nucleus, the morphology and synaptology of them were examined in the prese...

introduction: current study examined the possible role of the central nucleus of amygdala (cea) transient inactivation on the metabolic and hormonal disturbances induced by acute electro foot shock stress in female rats. considering the differences between female and male in responses to stress, this study attempts to reveal possible mechanisms underlying these differences. methods: uni- or bil...

introduction: nigrothalamocortical tract is one of the main outputs of the basal nuclei, but its role in motor disturbances is vauge, because there is little informations on its connection structure. some electrophysiological and pharmacological surveys report that none-dopaminergic outputs originate from reticular part of substantia nigra and end at thalamus. in this study the topographical co...