The Hyacinthaceae family (sensu APGII), with approximately 900 species in around 70 genera, plays a significant role in traditional medicine in Africa as well as across Europe and the Middle and Far East. The dichloromethane extract of the bulbs of Massonia pustulata (Hyacinthaceae sensu APGII) yielded two known homoisoflavonoids, (R)-5-hydroxy-3-(4-hydroxybenzyl)-7-methoxy-4-chromanone 1: and ...

9-Nitro-20(S)-camptothecin is a novel anticancer drug. In this study, metabolites of 9-nitro-20(S)-camptothecin in rats were identified. Rats were dosed with the drug, and the metabolites in the bile were isolated and collected by high-performance liquid chromatography using a gradient elution. By LC/MSn(n =1-3), the biliary metabolites in addition to the unchanged drug were identified as 9-ami...

Three quinolinone alkaloids, two acridone alkaloids and a flavones glycoside were isolated from the aerial parts of Glycosmis mauritiana. These compounds were characterized as 7, 8-Dimethoxy-2,2,6-trimethyl-pyrano quinolin-5-one, 4-Methoxy 1-methyl quinolin-2-one, 6-Hydroxy N-methyl 2,3-furo-quinolin-4-one, 1-Hydroxy-10-methyl acridone, 1Hydroxy-2, 3-dimethoxy-10-methylacridin-9-one and Luteoli...

Wittig rearrangement of 17(20)-ethylidene-16-furfuryloxy steroids 5–8 was examined. Reaction of 17E(20)-ethylidene-16afurfuryloxy steroid 5 with t-BuLi in THF afforded (20S,22S)and (20S,22R)-22-hydroxy steroids 9, 10 and 17Z(20)-ethylidene-16a-(2furyl)hydroxymethyl steroid 11 in 61, 28, and 9% yields, respectively. Base treatment of 17E(20)-ethylidene-16b-furfuryloxy steroid 7 gave (20R,22R)-22...

Eleven sesquiterpenoids have been isolated from the whole plants of Youngia japonica (Asteraceae). Among these sesquiterpenoids, five were identified as new compounds on the basis of spectroscopic methods and chemical analysis. Their structures were 3-oxo-8alpha-(4-hydoxyphenyl)acetoxy-10(14),11(13)-guaiadien-12,6-olide ( 1), 3beta-[3-(4-hydroxyphenyl)acetyl-beta- D-glucopyranosyloxy]-8alpha-hy...