Targeted α therapy (TAT) is a promising tool in the of cancer. The radionuclide 213BiIII shows favourable physical properties for this application, but fast and stable chelation metal ion remains challenging. Herein, we demonstrate that mesocyclic chelator AAZTA quickly coordinates BiIII at room temperature, leading to robust complex. A comprehensive study structural, thermodynamic kinetic [Bi(...

Neuroblastoma (NB) represents the most common extracranial tumor of childhood. Prognosis is quite variable, ranging from spontaneous regression to aggressive behavior with wide metastatization, high mortality, and limited therapeutic options. Radiotheranostics combines a radiopharmaceutical pair in unique approach, suitable both for diagnosis therapy. For many years, metaiodobenzylguanidine (MI...

PURPOSE The objective of this study was to determine the feasibility of exploiting the overexpression of somatostatin subtype-2 receptors (sstr(2)) on human medulloblastoma cells to develop targeted radiodiagnostics and radiotherapeutics for this disease. EXPERIMENTAL DESIGN The following radioiodinated peptides were prepared using chloramine-T and evaluated: [(131)I-Tyr(3)]octreotide ([(131)...

Neuroendocrine tumours (NETs) constitute a heterogeneous group of tumours that frequently express cell membrane-specific peptide receptors, such as somatostatin receptors (SSTRs), and of which gastroenteropancreatic (GEP), carcinoid and pancreatic islet cell tumours exhibit the highest expression of SSTRs. Radiolabelled receptor-binding somatostatin analogues (octreotide and lanreotide) act as ...