DEAR EDITOR, GNA11 and GNAQ are highly homologous genes encoding different Ga subunits of heterotrimeric G-proteins. We recently described postzygotic activating mutations in GNA11 or GNAQ as causes of phakomatosis pigmentovascularis (PPV), and GNAQ mosaicism as a cause of extensive dermal melanocytosis (EDM). GNAQ mosaicism has previously been found to cause Sturge–Weber syndrome (SWS) and iso...

strated by a proliferation associated a] Both the benign melanocytic hyperplasia. melanoma were diploid, which is consiste relatively benign tumours. Active prolif may have led to malignant degeneratioi stimulus which leads to active prolifera pre-existing anomalous melanocytes (t congenital uveal melanocytosis), is pr induced by a tumoral growth factor secreted by the primary tumour.1 The visu...

Nomenclature This pigmentary disorder is known by different names in various literatures. They are listed out here to avoid confusion. 1. Acquired bilateral nevus of Ota-like macules (ABNOM) 3, 10-13 2. Nevus fusco-caeruleus zygomaticus 4 3. Hori's nevus 10, 12,14 4. Acquired circumscribed dermal facial melanocytosis 5. In Taiwan, it is known as 褐藍色顴痣, which is translated from ''nevus fusco-cae...