to evaluate off-label and off-nccn guidelines uses of antineoplastic drugs in a major chinese hospital.totally 1122 patients were selected from july to december 2011. then, the off-label and off-nccn guidelines uses of antineoplastic drugs were analyzed.in 798 of 1122 patients (71.12%), drugs were used for off-label. in 317 of 1122 patients (28.25%), the drugs were prescribed for off-label and ...

Recently accumulated knowledge allows more precise comparison of the structural (and possibly evolutionary) relationships of several different animal rhabdoviruses: vesicular stomatitis virus, rabies virus, Kern Canyon virus, and spring viremia of carp virus. Each virus is composed primarily of a glycoprotein, an RNA-associated nucleoprotein, and one or two membrane proteins. Vesicular stomatit...

ATRIAS is a human-scale 3D-capable bipedal robot designed to mechanically embody the spring-mass model for dynamic walking and running. To help bring the extensive work on this theoretical model further into practice, we present the design and validation of a spring-mass robot that can operate in real-world settings (i.e. off-tether and without planarizing restraints). We outline the mechanisms...

Plants spend their entire life cycles rooted in one place. Thus, plant development, like the real estate business, is largely driven by location, location, location. A seedling emerges, perceives the hormonal and light signals that control its vegetative and reproductive development, finds and utilizes soil bound nutrient sources, and fends off hostilities wrought upon it by changing abiotic co...

The influence of spring stiffness and valve quality on the motion behaviors of reciprocating plunger pump discharge valves was investigated by fluid structure interaction (FSI) simulation and experimental analysis. The mathematical model of the discharge valve motion of a 2000-fracturing pump was developed and the discrete differential equations were solved according to FSI and results obtained...

This paper introduces a new concept in RF MEMS switches intended for high RF signal power applications at millimetre-wave operation. The novel SPST switch architecture employs electrothermal hydraulic microactuators. Out-of-plane silicon levers, having spring action and latching mechanisms, have been designed to create an OFF-state gap separation distance of 250 μm between ohmic contact electro...

Observations of unidentified EGRET sources were made with the Whipple 10m imaging atmospheric Čerenkov telescope between Fall 1999 and Spring 2001. During this period, a high resolution 490 pixel camera with 4 field of view was present on the telescope. Characterization of the off-axis response of this instrument was done using observations of the Crab Nebula. No significant emission was detect...

The bi-articular m. gastrocnemius and the mono-articular m. soleus have different and complementary functions during walking. Several groups are starting to use these biological functions as inspiration to design prostheses with bi-articular actuation components to replace the function of the m. gastrocnemius. Simulation studies indicate that a bi-articular configuration and spring that mimic t...

Western North Pacific gray whales (WGWs), once considered extinct, are critically endangered with unknown migratory routes and reproductive areas. We attached satellite-monitored tags to seven WGWs on their primary feeding ground off Sakhalin Island, Russia, three of which subsequently migrated to regions occupied by non-endangered eastern gray whales (EGWs). A female with the longest-lasting t...

The toxic effects of morphine sulfate in the adult cerebral cortex and one-day neonatal cerebellum have been studied. This study was carried out to evaluate the effect of maternal morphine exposure during gestational and lactation period on the Purkinje cells and cerebellar cortical layer in 18- and 32-day-old mice offspring. Thirty female mice were randomly allocated into cases and controls. I...