BACKGROUND & OBJECTIVES The emergence of resistance to fluoroquinolones in enteric fever despite the pathogen being susceptible by in vitro laboratory results, led to repeated changes in Clinical and Laboratory Standard Institute (CLSI) guidelines for this class of antibiotics to have specific and sensitive interpretative criteria. In 2015, CLSI added pefloxacin disk diffusion criteria as a sur...

objective: to compare the efficacy of ceftriaxone plus ofloxacin or azithromycin for cases of pelvic inflammatory disease (pid). materials and methods:   this clinical terial was performed on 180 women with pid from march 2005 to march 2007 in parastarane-shahed hospital. patients with pid were randomly divided to receive injection of ceftriaxone 250 mg plus ofloxacin 200 mg per day or azithrom...

A method for the determination of trace amounts of ofloxacin has been developed, based on solid-phase spectrofluorimetry. The relative fluorescence intensity of ofloxacin fixed on Sephadex SP C-25 gel was measured directly after packing the gel beads in a 1-mm silica cell, using a solid-phase attachment. The wavelengths of excitation and emission were 294 and 494 nm, respectively. The linear co...

Ofloxacin and ornidazole in combination are available as tablet dosage forms in the ratio of 2:5. A simple, reproducible and efficient method for the simultaneous determination of ofloxacin and ornidazole in synthetic mixture was developed. The proposed method is based on the Q-analysis UV Spectrophotometric method. The absorbance maxima of ofloxacin and ornidazole were found to be 286.2 nm and...

Aeromonas hydrophila was isolated from 12 (5.3%) of 225 patients with acute gastroenteritis.The present study was determined the virulence of A. hydrophila obtained from patients with diarrhea, among 12 A. hydrophila isolates obtained from stool, 83.3%, 91.6%, 83.3%, 75%, 75%, 50% produced β-haemolysin, protease ,phospholipase, DNase, slime(viscous glycoconjugate material), and have the adhesio...

The in vitro activity of ofloxacin (DL8280), a new pyridone carboxylic acid, against Chlamydia trachomatis serotype E was assessed by growth of chlamydia in cycloheximide-treated McCoy cells. Chlamydia-infected monolayers were exposed to the drug for 48 and 96 h and for 48 h followed by 48 h of further incubation after withdrawal of ofloxacin. Inclusions were visualized by indirect immunofluore...