Cervical cancer is a disease characterized by the growth of abnormal cells in cervical tissue. mostly caused Human Papillomavirus (HPV) types 16 and 18. The role genetic factors development malignancy mediated presence mutation HPV oncogene, especially oncogenes E6 E7. Oncogenic proteins E7 initiate dysregulation cellular proliferation apoptotic mechanisms targeting tumor suppressor proteins, s...

Transformation of fibroblast cells by v-abl oncogene involved overexpression of the c-myc (5) or of the cellular protein p53 (6). Two proto-oncogenes, cmyc and c-K-ras, have been shown to cooperate in the transformation of secondary rat embryo fibroblasts (7). Oncogenic activation of c-myc occurs mainly through constituve and elevated expression of its gene product and generally requires cooper...

The effects of an antisense oligodeoxynucleotide to codons 2-7 of the oncogene MYCN on the human neuroblastoma cell line LAN-5 were studied. Treated cells showed a decreased MYCN protein expression and synthesis by immunoperoxidase staining and immunoprecipitation. At the same time, the replication rate was inhibited, and the phenotype was modified toward a more differentiated type. Our data su...

knowledge about the clinical significance of v-raf murine sarcoma viral oncogene homolog b1 ( braf ) mutations in colorectal cancer (crc) is growing. braf encodes a protein kinase involved with intracellular signaling and cell division. the gene product is a downstream effector of kirsten ras 1( kras ) within the ras/raf/mapk cellular signaling pathway. evidence suggests that braf mutations, li...

Deptor is a protein that interacts with mTOR and belongs to the mTORC1 mTORC2 complexes. capable of inhibiting kinase activity mTOR. It well known pathway involved in various signaling pathways are biological processes such as cell growth, apoptosis, autophagy, ER stress response. Therefore, Deptor, being natural inhibitor mTOR, has become very important its study. Because this, it research rol...

BACKGROUND The RET proto-oncogene encodes a protein that belongs to the tyrosine kinase growth factor receptor family. Germline point mutations in RET are found in individuals with multiple endocrine neoplasia (MEN) syndromes, and gene rearrangements have been reported in papillary thyroid cancers. We recently identified transcripts of the RET proto-oncogene in human prostate cancer xenografts ...

The Philadelphia chromosome was the first specifıc karyotype abnormality associated with a particular neoplastic disease in humans. Ph translocation generats hybrid gene consisting of 5' exon sequences bcr on 22 fused to 3' exons and polyadenylation/termination ABL proto-oncogene from 9. molecular consequence this is transcription chimaeric m RNA transcribed novel 210 kd protein (p 210) CML, an...

Objective: Circulating progenitor cells possess vasculogenesis property and participate in repair of vascular injury. Cx (connexin) 43—a transmembrane protein constituting gap junctions—is involved pathology. However, the role Cx43 smooth muscle (SPCs) remained unclear. Approach Results: Human SPCs cultured from CD34 + peripheral blood mononuclear expressed cell markers, such as MHC (myosin hea...

The multifunctional BAG-1 (Bcl-2 athanogene-1) protein promotes breast cancer survival through direct or indirect interaction partners. number of the interacting partners determines its cellular role in different conditions. As well as partner variability, amount cells could cause dramatic alterations. According to previous studies, while transient silencing Bag-1 enhanced drug-induced apoptosi...

The human bcr gene encodes a protein with serine/threonine kinase activity, CDC24/dbl homology, a GAP domain, and an SH2-binding region. However, the precise physiological functions of BCR are unknown. Coexpression of BCR with the cytoplasmic protein-tyrosine kinase encoded by the c-fes proto-oncogene in Sf-9 cells resulted in stable BCR-FES protein complex formation and tyrosine phosphorylatio...