An efficient and expeditious catalyst-free procedure was developed for the one- pot synthesis of 1, 4-dihydropyridine derivatives via the three-component reaction of various aldehydes, ethyl acetoacetate, and ammonium acetate in PEG-400. The reaction was carried out at 110°С and the products were obtained in good to high yields.

A green and efficient one-pot synthesis of benzylamino coumarin derivatives was conducted by a three-component condensation of 4-hydroxycoumarin, cyclic secondary amine, and aromatic aldehyde in the presence of CuO nanoparticles (NPs) as a heterogeneous catalyst in water at room temperature. 

Nano-rice bran/TiCl4has been prepared from rice bran and TiCl4 in n-hexane as solvent. Thennanoricebran/TiCl4 has been introduced as a novel catalystfor the three component synthesis of pyrano[3,2-b] pyransfrom the simple one-pot reactionbetweenaryl aldehydes,cyanoacetamide and kojicacid.Cleanliness, an eco-friendly catalyst, simple methodology, short time, and excellent yields ofproducts are s...

a very efficient one-pot three-component synthesis of pyran derivatives has been improved by condensation of aldehydes and malononitrile with dimedone under 80 °c using sucrose as natural and biodegradable catalyst in water. this method offers some advantages including inexpensive, high to quantitative yields, short reaction time, and easy work-up. therefore, this methodology is entirely green ...