New treatment options are needed for medullary thyroid carcinoma (MTC), a highly metastasizing neuroendocrine tumor that is resistant to standard radiotherapy and chemotherapy. We show that the following shikonin derivatives inhibit cell proliferation and cell viability of the MTC cell line TT: acetylshikonin, β,β-dimethylacrylshikonin, shikonin and a petroleum ether extract of the roots of Ono...

This work deals with the effects of the alcoholic extracts of 15 plants (collected from the northern region of Pakistan) on isolated guinea-pig ileum preparation. Dried powdered plant material was extracted with alcohol. The extract obtained after the removal of the alcohol was triturated with pet-ether (40-60°) and then charcoaled, filtered and dried under vacuum. The isolated guinea-pig ileum...

Türkiye için endemik ve dar yayılışlı türler olan Onosma beyazoglui Kandemir & Türkmen Psephellus erzincani Wagenitz Kandemir, Erzincan ili İliç Kemah ilçelerindeki jipsli alanlarda yetişmektedir. Bu araştırmada, bu iki türe ait IUCN tehlike kategorilerinin güncellenmesi türlerin korunması izleme planlarının oluşturulması amaçlanmıştır. kapsamda, 2020-2021 yılları arasında vejetasyon dö...