Introduction: Recent studies have shown the presence of Cl- channels in heart and liver mitochondrial membranes. In this work, we have characterized the functional profile of a Cl- channel from rat brain mitochondria. Methods: After removing and homogenizing the rat brain, the supernatant was separately centrifuged in MSEdigitonin, H2O and Na2CO3 and mitochondrial inner membrane vesicles wer...

Introduction: Different ATP-sensitive potassium channels have been detected in the mitochondrial inner membrane of cells. They are suggested to be involved in cell processes including cell protection. Here, we characterized the biophysical and electropharmacological properties of a KATP channel in the brain mitochondrial inner membranes. Methods: After removing and homogenizing the rat brain...

Abs t r ac t . The Multimedia Multicast Channel is a dissemination-oriented communication abstraction providing a service analogous to that of a cable television broadcast channel. A source transmits multimedia information such as video and audio streams onto a channel, and a varying number of receivers "tune in" to the channel to receive a selected set of the streams. To support heterogeneity~...

Voltage-gated potassium (Kv) and sodium (Nav) channels are key determinants of cellular excitability and serve as targets of neurotoxins. Most marine ciguatoxins potentiate Nav channels and cause ciguatera seafood poisoning. Several ciguatoxins have also been shown to affect Kv channels, and we showed previously that the ladder-shaped polyether toxin gambierol is a potent Kv channel inhibitor. ...

The objective of this article is to conceptually transfer the concept of open source software (OSS) development to scientific entrepreneurship and to hypothetically discuss the support potentials of this rather new development philosophy for what we than call open scientific entrepreneurship. Therefore, at first the authors will go into conceptual details of scientific entrepreneurship and than...