The propagation of molecules, ions and electrochemical signals in various cell types occurs through hundreds gap junction channels. A channel is composed units which are further decomposed to hemichannels. From the computational modeling perspective, each acts as a state machine, switching between different permeability states at known rates. Both permeabilities rates jointly depend on transmem...

Forced expression of gap junction proteins, connexins, enables gap junction-deficient cell lines to propagate intercellular calcium waves. Here, we show that ATP secretion from the poorly coupled cell lines, C6 glioma, HeLa, and U373 glioblastoma, is potentiated 5- to 15-fold by connexin expression. ATP release required purinergic receptor-activated intracellular Ca2+ mobilization and was inhib...

Introduction: Previous studies and our works have indicated several cation channels in the rat brain mitochondrial inner membrane. In this work, we report the single-channel characterization of a cation channel from the rat brain mitochondrial inner membrane incorporated into a planar lipid bilayer. Methods: After removing and homogenizing the adult rat brain, its supernatant was centrifuged...

A Silicon tunnel FET with Si1-x Gex source is investigated and optimized for improved performance. In order to optimize the device performance, Germanium mole fraction and the length of the SiGe region is varied and the optimum values are obtained. Moreover, the source/channel hetero-junction is assumed graded. The grading distance is varied from zero (abrupt hetero-junction) to total channel l...

introduction: recent studies have shown the presence of cl- channels in heart and liver mitochondrial membranes. in this work, we have characterized the functional profile of a cl- channel from rat brain mitochondria. methods: after removing and homogenizing the rat brain, the supernatant was separately centrifuged in msedigitonin, h2o and na2co3 and mitochondrial inner membrane vesicles were o...