Ocular drug delivery in hydrogel forming film form has several benefits over conventional dosage forms. An ophthalmic anti-inflammation study was undertaken using topically applied aspirin a formulation. A hydroxypropyl methylcellulose (HPMC) matrix formulation prepared by the solvent casting and evaporation technique taking triethanolamine (TEA) as plasticizer. Ex vivo corneal permeation well ...

The function of a photocrosslinked poly(propylene fumarate) (PPF)/poly(N-vinyl pyrrolidone) (PVP) matrix for the sustained release of three ophthalmic model drugs, acetazolamide (AZ), dichlorphenamide (DP), and timolol maleate (TM), was investigated. The drugs differ in molecular weight and degree of dissociation in aqueous environments; both are parameters that significantly influence drug dif...

Ocular drug delivery is a very challenging area for ophthalmologists and scientists due to the structural barrier complexity of eye. Barriers such as different layers cornea, sclera, conjunctival blood flow, tear dilution limit efficacy anterior part eye in addition more barriers present posterior part. Due these, have designed studied various systems increase treatment Among conventional ocula...

„Ocular drug delivery is one of the most interesting and challenging endeavours facing the pharmaceutical scientist...The anatomy, physiology and biochemistry of the eye render this organ exquisitely impervious to foreign substances...The challenge to the formulator is to outwit the protective barriers of the eye without causing permanent tissue damage...The ancient ophthalmic solutions, suspen...

tion (AMD), glaucoma, dry eye and diabetic retinopathies is increasing steadily. Drug treatment for ocular diseases is challenging due to the complex and protected structure of the eye, which prevents the penetration of active compounds at the site of action, e.g. the retina, after systemic administration. Although topical administration of eye drops is an easy and non-invasive method of ocular...

It is common knowledge that the ocular bioavailability and therapeutic response of drugs applied topically as eye drops is very poor, this is due to rapid precorneal drainage of the instilled dose, which could be overcome by the use of in-situ gelling systems that undergo a sol-gel transition in the cul-de-sac. This work describes the ophthalmic formulation of an antibacterial agent ofloxacin, ...

Topical route of administration is the most commonly used method for the treatment of ophthalmic diseases. However, presence of several layers of permeation barriers starting from the tear film till the inner layers of cornea make it difficult to achieve the therapeutic concentrations in the target tissue within the eye. In order to circumvent these barriers and to provide sustained and targete...

Corneal Regeneration In article 2300192 by Lixin Xie, Qingjun Zhou, and co-workers, a photoreactive adhesive hydrogel that mimics the extracellular matrix (mainly composed of gelatin hyaluronic acid) is designed to treat large-diameter (≥6 mm) corneal defects, which effectively promotes epithelial, stromal, neural regeneration while preventing scar formation. It also holds great improvement exp...

OBJECTIVE Red reflex test is an effective screening tool in the early diagnosis of neonatal eye abnormalities. The aim of this study was to detect the sensitivity and specificity of red reflex assessment in neonates, performed by pediatricians (or other care providers) in comparison with ophthalmologists. Also association between red reflex findings and neonatal variables is evaluated. METHOD...