objective: many psychodynamic oriented psychotherapists believe that people do not become addicted without a reason they use drugs to avoid painful feelings, thoughts and memories. the present study examines the relationship between the level of dissociation, substance dependence disorder and other psychiatric disorder. methods: in a descriptive study on prisoners of adel-abad prison, shiraz, i...

Guidance for the use of substitute prescribing in the treatment of opioid dependence in primary care Acknowledgements: Thanks to the Royal College of General Practitioners (RCGP) Regional Leads and the many others, who have contributed to developing this guide. a) These guidelines have been: Updated in line with Guidance on methadone and buprenorphine for the management of opioid dependence and...

The study aimed to examine the association of impulsivity and screening positively for borderline personality disorder (BPD+) as risk factors for suicide attempts among opioid-dependent individuals. The study used a case-control design with 775 opioid-dependent cases and 306 non-opioid-dependent controls. Cases were more likely than controls to screen BPD+ and to be classed as highly impulsive....

This review will introduce the concept of toll-like receptor (TLR)-mediated glial activation as central to all of the following: neuropathic pain, compromised acute opioid analgesia, and unwanted opioid side effects (tolerance, dependence, and reward). Attenuation of glial activation has previously been demonstrated both to alleviate exaggerated pain states induced by experimental pain models a...

Buprenorphine/naloxone (Suboxone) comprises the partial mu-opioid receptor agonist buprenorphine in combination with the opioid antagonist naloxone in a 4 : 1 ratio. When buprenorphine/naloxone is taken sublingually as prescribed, the naloxone exerts no clinically significant effect, leaving the opioid agonist effects of buprenorphine to predominate. However, when buprenorphine/naloxone is pare...

BACKGROUND Opioid dependence (OD) is a chronic, relapsing condition representing a significant societal burden in Asia. Opioid maintenance treatment (OMT) in combination with psychosocial treatment is considered to be the most effective strategy to treat opioid dependence. In Malaysia, about 52,000 patients reported receiving OMT in December 2012. OBJECTIVE The International Survey Informing ...