نتایج جستجو برای: opioid substance
تعداد نتایج: 236027 فیلتر نتایج به سال:
Substance abuse has become one of the major contributor to psychiatric morbidity worldwide. The pattern of substance abuse, in patients attending psychiatry OPD of IGMC, Shimla, from the years 2006 to 2008, was studied. Alcohol abuse was found to be the most prevalent, followed by that of cannabis. Opioid, sedative and inhalant abuse trends were found increase over these years.
Opioid use disorders and overdose have become a major public health concern in recent years. U-47700, New psychoactive substances (NPS) opioid, also known as “pinky” or “pink” has been identified new threat the drug supply because of its potency abuse potential. Conjugate vaccines that can produce antibodies against target molecules emerged promising tool to treat substance disorders. Herein, w...
BACKGROUND The consequences of opioid relapse among patients being treated with opioid substitution treatment (OST) are serious and can result in abnormal cardiovascular function, overdose, and mortality. Chronic pain is a major risk factor for opioid relapse within the addiction treatment setting. There exist a number of opioid maintenance therapies including methadone, buprenorphine, naltrexo...
BACKGROUND The prevalence, efficacy, and risk for addiction for persons receiving opioids for chronic back pain are unclear. PURPOSE To determine the prevalence of opioid treatment, whether opioid medications are effective, and the prevalence of substance use disorders among patients receiving opioid medications for chronic back pain. DATA SOURCES English-language studies from MEDLINE (1966...
Intrathecal (i.t.) pretreatment with a low dose (0.3 nmol) of morphine causes an attenuation of i.t. morphine-produced analgesia; the phenomenon has been defined as morphine-induced antianalgesia. The opioid-produced analgesia was measured with the tail-flick (TF) test in male CD-1 mice. Intrathecal pretreatment with low dose (0.3 nmol) of morphine time dependently attenuated i.t. morphine-prod...
OBJECTIVE To evaluate the clinical observation that the number of individuals seeking opioid detoxification from oxycodone was increasing at the Centre for Addiction and Mental Health (CAMH) in Toronto, Ont; and to identify the characteristics of individuals seeking opioid detoxification at CAMH. DESIGN Retrospective analysis of patient health records. SETTING Medical Withdrawal Management ...
PURPOSE Prescriptions for hydrocodone immediate-release (IR) combination products have recently decreased, yet they represent the majority of opioid prescriptions dispensed and are commonly abused analgesics among both adults and adolescents. Little data exist to understand the contribution of IR products to the problem of prescription opioid abuse. This study aimed to better understand abuse p...
Introduction Opioids have been viewed for centuries as the most effective treatment for chronic pain, yet in the past decade the misuse of prescription opioids has become a The number of prescriptions filled for opioid pain relievers—some of the most powerful medications available—has increased dramatically in recent years. From 1997 to 2007, the milligram per person use of prescription opioids...
There is a concerted research effort to investigate brain mechanisms underlying addiction processes that may predicate the development of new compounds for treating addiction. One target is the brain's opioid system, because of its role in the reinforcing effects of substances of abuse. Substance-dependent populations have increased numbers of the mu opioid receptor (MOR) in fronto-striatal reg...
BACKGROUND Polymorphisms in the μ-, δ- and κ-opioid receptor genes (OPRM1, OPRD1 and OPRK1) have been reported to be associated with substance (alcohol or drug) dependence. The influence of an individual gene on a disease trait should be more evident when analyzed in the context of gene-gene interactions. Thus, we assessed the joint effect of variants in these three opioid receptor genes on alc...
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