purpose: to evaluate the relationship between central corneal thickness (cct) and optic disc area in patients with primary open angle glaucoma (poag). methods: the study was performed on patients with poag who were being followed at johns hopkins hospital. all patients underwent thorough eye examination, optic disc imaging with the heidelberg retina tomograph ii (hrt ii), and ultrasound corneal...

Purpose. To evaluate the relationship between the macular ganglion cell complex (mGCC) thickness, which is the sum of the retinal nerve fiber, ganglion cell, and inner plexiform layers, measured with a spectral-domain optical coherence tomograph and the optic nerve head topography measured with a confocal scanning laser ophthalmoscope in glaucomatous eyes with visual field defects localized pre...

  Background :There is not any data available about the effect of high bar pressure condition on intracranial pressure. In this study, the effect of diving on the optic nerve and sheath diameters as non-invasive markers of intracranial pressure has been investigated.   Methods : Twenty professional male divers from twenty one volunteers were chosen for this cross-sectional study. Only one perso...

Optic nerve head drusen can be associated with peripapillary choroidal neovascularization, in both the pediatric and adult population. These membranes can involve the macula, causing significant visual loss. Herein, we present a case that required treatment with an anti-VEGF agent. The patient failed to respond to the initial agent, but subsequently responded to a change of agent. Adult patient...

I ntraocular pressure (IOP) is well known to play an important role in the pathogenesis of some forms of glaucoma. Furthermore, significant, sustained pressure reduction is known to be beneficial in the clinical management of glaucoma patients. 1 Less well understood is the mechanism by which elevated IOP leads to the loss of retinal ganglion cells that is the hallmark of glaucomatous optic neu...

PURPOSE Biomechanical factors have been implicated in the development of glaucomatous optic neuropathy, particularly at the level of the lamina cribrosa. The goal of this study was to characterize the biomechanics of the optic nerve head using computer modeling techniques. METHODS Several models of the optic nerve head tissues (pre- and postlaminar neural tissue, lamina cribrosa, central reti...

PURPOSE In both animal model system and in human glaucoma, retinal ganglion cells (RGCs) die by apoptosis. To understand how RGC apoptosis is initiated in these systems, the authors studied RGC neurotrophin transport in experimental glaucoma using acute intraocular pressure (IOP) elevations in rats and chronic IOP elevation and unilateral optic nerve transections in monkeys. METHODS Eyes were...